MUSCLE MATRIX AND BLADDER FUNCTION

描述：(改编自申请人的摘要)尿失禁 是一个估计有1000万各个年龄段的美国人面临的问题，而且是一个 导致老年人制度化的主要原因。膀胱出口 继发于良性前列腺肥大(BPH)的梗阻也是一个主要原因。 当人们考虑到100亿美元时，国家面临的医疗问题 (保守的数字是400,000次前列腺切除术)每年花费在 这种疾病的外科治疗。前列腺增生症的主要症状是 继发梗阻对膀胱平滑肌的影响。这个 据估计，国家每年为这两个医疗问题付出的代价是 200亿美元。这些膀胱功能障碍的症状中有许多可能是 由医学管理，但目前可用的药理药物是 过时了，不够有效。需要更多的基础科学 了解正常人膀胱平滑肌发育的研究 胎儿和新生儿时期，它如何随年龄变化(在男性和 雌性)，以及它如何应对障碍物。建议的目的是 会议是将膀胱畅通的主要研究小组聚集在一起 肌肉生理学是一种思想和信息的交流。20人的田野 主要演讲者(大多数人一直在下尿路工作 生理学至少3年)将介绍他们实验室的工作 30分钟，然后进行简短的讨论。将有4个开放的45 小组讨论纪要。目标是为每个主要演讲者提供 一个论坛，详细讨论他们正在进行的工作，并深入了解 来自其他小组成员和听众的建设性反馈。一个 将安排张贴海报的环节，以吸引年轻人或新人的工作 调查人员赶到现场。所有出席的调查人员都将被邀请 将他们的工作贡献给一本专著，该专著将由全会出版。 这次会议将是独一无二的，原因有几个：1)从来没有 如此深入的会议专门讨论了平滑肌肉的话题 下尿路的功能；2)它将掩盖正常的变化 从胎儿开始一直到正常的膀胱生理学 成长和成熟；3)将详细介绍目前对 出口阻塞对血管平滑肌功能的影响；及 除了讨论平滑肌功能的细胞内基础外， 本次会议还将重点讨论细胞外基质的作用。 以及它如何影响尿液的主动和被动特性 膀胱。

DESCRIPTION: (Adapted from the applicant's abstract) Urinary incontinence is a problem for an estimated 10 million Americans of all ages, and is a leading cause for institutionalization of the elderly. Bladder outlet obstruction secondary to benign prostatic hypertrophy (BPH) is also a major medical issue facing the nation when one considers that 10 billion dollars (a conservative figure for 400,000 prostatectomies) is spent yearly on surgical management of the disease. The major symptoms of BPH are secondary to the effects of obstruction on bladder smooth muscle. The annual cost to the nation for these 2 medical problems is estimated to be 20 billion dollars. Many of these symptoms of bladder dysfunction could be managed medically, but the current pharmacologic agents available are outdated and not effective enough. There is a need for more basic science research to understand how bladder smooth muscle develops in the normal fetal and newborn period, how it changes with aging (in both males and females), and how it responds to obstruction. The purpose of the proposed conference is to bring together the major research groups in bladder smooth muscle physiology for an exchange of ideas and information. A field of 20 primary speakers (most of whom have been working in lower urinary tract physiology for at least 3 years) will present their laboratory's work for 30 minutes followed by a brief discussion period. There will be 4 open 45 minute panel discussions. The goal is to provide each primary speaker with a forum to discuss their ongoing work in detail, and receive in depth constructive feedback from their fellow panelists and the audience. A poster session will be arranged to attract work from young or new investigators to the field. All investigators who attend will be invited to contribute their work to a monograph which will be published by Plenum. The conference will be unique for several reasons: 1) there has never been such an in depth conference devoted solely to the topic of smooth muscle function of the lower urinary tract; 2) it will cover the changes in normal bladder physiology that occur beginning in the fetus and on through normal growth and maturation; 3) it will cover in detail the current understanding of the effects of outlet obstruction on smooth muscle function; and 4) in addition to discussing the intracellular basis for smooth muscle function, this conference will also focus in on the role of the extracellular matrix and how it may influence the active and passive properties of the urinary bladder.