SIMULATED BEDREST AND TREATMENT EFFECTS ON AGING MUSCLE

这项研究将检查骨骼肌和骨骼的变化，因为 幼年和老年大鼠的模拟卧床休息。主要的假设是 研究表明，模拟卧床休息对骨骼肌更有害 而且老年大鼠的骨骼比年轻大鼠的要大。我们将在中检查这两个更改 肌肉收缩功能与可能的组织化学和生化 卧床休息后肌肉功能的相关性。我们还将评估 骨强度变化与骨矿物质分析 内容物和潜在的组织学改变。各种治疗，都是 其中可用于临床以尝试改善有害的 卧床休息的效果，将在幼年和老年动物身上使用。治疗 预计结果将为临床医生提供策略指导。 对于需要卧床休息的患者，这一点可以很容易地使用。这个 申请者在治疗以下老年人方面有丰富的经验 长时间卧床休息的时间。她的临床观察使她开始 探讨卧床休息导致功能改变的一些原因 一种动物模型，可以更深入地评估这些 效果。此外，这些研究应增进对 在老龄化背景下卧床休息和康复的影响。

This research will examine changes in skeletal muscle and bone due to simulated bedrest in young and old rats. The primary hypothesis to be examined is that simulated bedrest is more detrimental to skeletal muscle and bone in old than in young rats. We will examine both changes in muscle contractile function and possible histochemical and biochemical correlates of muscle function following bedrest. We will also evaluate changes in bone strength in conjunction with analysis of bone mineral content and potential histological alterations. Various treatments, all of which may be used clinically to attempt to ameliorate the detrimental effects of bedrest, will be employed in young and old animals. Treatment outcomes are expected to provide guidance for the clinician on strategies that may be employed readily for patients on required bedrest. the applicant has extensive experience with treating older adults following periods of prolonged bedrest. Her clinical observations led her to begin exploring some of the reasons for functional changes due to bedrest using an animal model which allows for more in depth evaluation of these effects. In addition, these studies should enhance understanding of the effects of bedrest and rehabilitation within an aging context.