RESYNTHESIS OF COMPOUNDS FOR SCREENING

通过药物合成和化学鉴定的化合物 NCI抗HIV和抗肿瘤筛查测试的分支包括 各种自愿捐赠的化合物和那些被要求 从他们的作者从出版的最新文献的基础上， 其结构新奇或相关性。 最后一类化合物 通常是无法使用的程序。 也会出现以下情况： 由于原始的 捐助者不能提供额外的样品或一小系列的结构 相关化合物。 该服务项目提供了编制 筛选所需的这些有机或无机化合物， 发展方案。 多达200个化合物可能会分配给承包商超过 这个项目的生命。 工程的规模通常涉及 要求提供100 mg至5 mg范围内的最终化合物样品 克. 已发表文献中的特定实验条件 将在大多数情况下可用。 一些过程开发 在详细程序不可靠的情况下， 或不可用。 合同机制被认为是最适当的工具， 满足要求，因为： 拟采购的化合物不是库存目录项目;成功 指定化合物的制备将需要大量的技术 项目负责人的指导。 合同允许优先获得化合物 政府控制的基础和时间框架， 政府的利益或使用。

Compounds identified by the Drug Synthesis and Chemistry and Chemistry Branch for testing in the NCI's anti HIV and antitumor screens consist variously of voluntarily donated compounds and those which are requested from their authors from the published recent literature on the basis of their structural novelty or relevance. Compounds in this last category are often not available to the program. Situations also arise where follow up testing of a lead is precluded by the fact that the original donor cannot provide additional sample or a small series of structurally related compounds. This service project provides for the preparation of these organic or inorganic compounds required by the screening and development programs. As many as 200 compounds may be assigned to the contractors over the life of this project. The scale of the Work will typically involve a request for samples of final compounds in the range of 100 mg to 5 grams. Specific experimental conditions from the published literature will be available in the majority of cases. Some process development may be required in instances where detailed procedures are not reliable or are unavailable. The contract mechanism is deemed the most appropriate instrument for fulfilling the requirement because: The compounds to be acquired are not stock catalogue items; successful preparation of the assigned compounds will require significant technical direction by the Project Officer. A contract allows for the acquisition of the compounds on a priority basis and time frame controlled by the Government, for the direct benefit or use of the Government.