HAEMOPHILUS INFLUENZAE TYPE B REFERENCE LABORATORY

对流感嗜血杆菌参考实验室的支持 血清学分析和疫苗供应是 NIAID的脑膜炎疫苗项目。血清学参考实验室 将作为反PRP标准化测量的协调中心 流感嗜血杆菌引起的儿童自然疾病的抗体反应 感染，成人和儿童接种候选H. 流感疫苗。该项目还将提供试剂级PRP和 将放射性标记的PRP提供给其他研究人员用于化验。没有 此时承包商是否需要向其他人员提供PRP疫苗 调查人员，因为几家疫苗制造商现在正在销售这种产品 让它变得可用。几个实验室目前正在调查 基于PRP的疫苗。抗体检测的性能在相同的 使用相同程序和试剂的实验室将允许 不同患者群体和候选疫苗之间的比较。

The support of a H. influenzae reference laboratory for performing serological analyses and supplying vaccine is an integral component of the Meningitis Vaccine Program at the NIAID. The serologic reference laborator would serve as a focal point for the standardized measurement of anti-PRP antibody responses in children with natural disease due to H. influenzae infection, and in adults and children vaccinated with candidate H. influenzae vaccines. The project would also supply reagent grade PRP and radiolabeled PRP to other investigators for assay purposes. There is no need at this time for the contractor to provide PRP vaccine to other investigators since several vaccine manufacturers now market this product and make it available. Several laboratories are currently investigating PRP-based vaccines. The performance of antibody assays in the same laboratory using the same procedures and reagents would allow for comparisons between various patient populations and candidate vaccines.