IN VITRO EVALUATION/CHEMICAL CANDIDATES IN VIVO TESTING

癌症病因科主任办公室多年来， 已经签订了执行诱变性分析的合同(小鼠淋巴瘤L5178Y Tk+/-)支持该司的校外和校内活动， 特别强调提供用于NCI的体外数据 致癌性指定化学品的化学选择过程 测试，给国家毒理学项目。因为通常会有一个 缺乏关于正在考虑的化学品的体外数据，信息 从这些化验中获得的最重要的是允许成员 化学品选择工作组(CSWG)在#年做出明智的决定 一种及时的时尚。此采购的目标是执行鼠标 淋巴瘤L5178Y TK+/-检测及报告20-30种化合物 年，大约三分之一的化合物需要额外的检测 在最终报告写出来之前。

The Office of the Director, Division of Cancer Etiology, for many years, has had a contract to perform mutagenicity assays (Mouse Lymphoma L5178Y TK+/-) in support of extramural and intramural activities of the Division, with particular emphasis on providing in vitro data for use in the NCI chemical selection process of chemicals nominated, for carcinogenicity testing, to the National Toxicology Program. Since there is often a paucity of in vitro data on chemicals under consideration, the information obtained from these assays is most important in permitting the members of the Chemical Selection Working Group (CSWG) to make informed decisions in a timely fashion. The objective of this procurement is to perform Mouse Lymphoma L5178Y TK+/- assays and report on between 20-30 compounds per year, with about one third of the compounds requiring an additional assay before the final report is written.