SUBCHRONIC AND CHRONIC STUDIES OF OXAZEPAM

该项目的目标是表征：剂量-反应 奥沙西潘在饲料中的投药关系及毒性 对大鼠和小鼠进行为期90天的亚慢性和2年慢性研究。 每周7天给动物喂食，为期90天。 或者两年。在每项研究结束时，所有的动物都将被给予 大体和显微组织病理学检查，精子 形态/阴道细胞学、神经行为评估和血液 奥沙西潘的浓度将在90天的研究中进行评估。一个 65周中期处死动物，包括组织病理学和血液 奥沙西潘浓度将在这项慢性研究中进行评估。 此外，还将优先评估特殊的神经行为指标。 到慢性研究开始，在6、12、18和24个月时 慢性研究的一部分。这项为期90天的研究结果将用于 由NTP确定用于慢性研究的剂量。这个 慢性研究的结果将被用于评估 奥沙西潘的毒理学和致癌潜力。

The objective of this project is to characterize:dose-response relationships and toxicity of oxazepam administered in dosed feed to rats and mice in 90-day subchronic and 2-year chronic studies. Animals will be administered dosed feed 7 days per week for 90 days or 2 years. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations, Sperm morphology/vaginal cytology, neurobehavioral evaluations, and blood oxazepam concentrations will be evaluated in the 90-day study. A 65-week interim sacrifice including histopathology and blood oxazepam concentrations will be evaluated in the chronic study. In addition, special neurobehavior indices will be evaluated prior to the start of the chronic study and at 6, 12, 18, and 24 months of the chronic study. The results of the 90-day study will be used by NTP to establish doses to be used in the chronic study. The results of the chronic study will be utilized in evaluation of the toxicologic and carcinogenic potential of oxazepam.