REVIEW AND ANALYSIS ON ENVIRONMENTAL MUTAGENESIS

本合同的目的是提供有关化学品的信息 致突变性、致染色体断裂性和遗传毒性潜力，基于 出版的文献。 为了达到这个目的，一种化学物质在生物学上 相关代谢物、结构类似物和光学异构体将被 鉴定 此外，还将检查每种化学品是否存在 结构上的警戒性亲电特征 文学将是 检索了致突变性、致染色体断裂性和遗传毒性的信息 这些化学品的潜力和化学品中的参考资料， 有助于理解分子机制的生物学文献 将检索、评价和 总结在一份报告中。 这些信息将有助于形成更好的 根据遗传毒性，了解化学品的遗传毒性潜力 自身及相关化学品的影响。 承包商将生产 五个国家中的每一个国家每年提交45份但不超过60份报告， 合同年。

The purpose of this contract is to provide information on a chemical's mutagenic, clastogenic, and genotoxic potential based on data in the published literature. To accomplish this, a chemical's biologically relevant metabolites, structural analogs, and optical isomers will be identified. In addition, each chemical will be examined for the presence of structurally alerting, electrophilic features. The literature will be searched for information on the mutagenic, clastogenic, and genotoxic potential of these chemicals and references in the chemical and biological literature that aid in understanding the molecular mechanism of the chemicals mutagenic activity will be retrieved, evaluated, and summarized in a report. This information will aid in forming a better understanding of a chemical's genotoxic potential based on the genotoxic effects of itself and related chemicals. The contractor will produce between 45 but no more than 60 reports per year for each of the five contract years.