BRAIN AND TISSUE BANK FOR DEVELOPMENTAL DISORDERS

该项目的目标是系统地收集和分发 高质量的活组织检查和/或来自“未受影响”的新鲜尸检组织 （对照）个体和已被诊断为患有 已知或未知形式的精神发育迟滞，发育性 残疾或婴儿猝死综合症死亡的婴儿 （SIDS）。 在获取标本的条件中， 包括那些具有染色体缺陷、线粒体 肌脑病、苯丙酮尿症和其它氨基酸病， 有机酸尿症，母体苯丙酮尿症，雷特综合征，脑白质营养不良， 溶酶体胆积症、阅读障碍、自闭症和其他 神经发育障碍 该储存库将作为一个研究 合格研究人员的资源，以支持和促进研究 这将导致对病因学，病理学， 发病机制和临床病理相关性的条件， 与婴儿猝死综合症、智力迟钝、学习和行为障碍有关。 赤字 因为储藏室会收集正常和异常的大脑 在不同的产前和产后发育阶段， 为大脑发育的纵向研究提供材料， 其畸形。

The objective of this project is to systemically collect and distribute high quality biopsy and/or freshly autopsied tissues from "unaffected" (control) individuals and from patients who had been diagnosed to have a known or unknown forms of mental retardation, developmental disabilities, or infants who dies of sudden infant death syndrome (SIDS). Among the conditions from whom specimens will be obtained include those with chromosome defects, mitochondrial myoencephalopathies, phenylketonuria and other aminoacidopathies, organic acidurias, maternal PKU, Rett syndrome, leukodystrophies, lysosomal storage disorders, dyslexia, autism, and other neurodevelopmental disorders. The repository will serve as a research resource for qualified investigators to support and facilitate research that will lead to an improved understanding of the etiology, pathology, pathogenesis, and clinical-pathological correlation of conditions that are associated with SIDS, mental retardation, learning and behavioral deficits. Since the repository will collect normal and abnormal brains at various prenatal and postnatal stages of development, it can also provide material for the longitudinal studies of brain development and its malformations.