Edinburgh Brain and Tissue Bank

爱丁堡脑和组织库

• 批准号: G1100616/1
• 负责人: Colin Smith
• 金额: $ 64.08万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100616%2F1
• 关键词: Edinburgh; Brain; Tissue; Bank

Scientific research ultimately aims to improve the health and wellbeing of the public. To achieve this we need to understand the mechanisms of disease such that we may try to develop new treatments. Diseases of the nervous system in particular cause considerable suffering not just to the individual but also to the carers. To better understand disease processes requires the study of animal models, to try and work out the mechanisms of a disease, and then translation of these mechanisms to the human setting. It is in this translation that collected human material, obtained at autopsy with the full consent of the next of kin, is invaluable. It is through the donation of tissues to scientific research that some carers are able to achieve peace of mind that some good may come from the death of a family member. Brain tissue has been collected for many years from cases of long-term neurological diseases such as dementia and multiple sclerosis, and Edinburgh is an internationally recognised centre in prion brain banking. In the setting of sudden death, where the bereavement is often felt more acutely due to the unexpectedness of the death and often due to the young age of the individuals involved, donating tissues to scientific research has previously not been an option available to the next of kin. The MRC funded Edinburgh brain and tissue bank provides this opportunity. Although many individuals dying suddenly may have no neurological disease at the time of death, their tissues can provide valuable information when compared to brain of an individual with established neurological disease. This control function of normal brain tissue is essential to investigation of all brain disorders and is as important as getting access to tissue from brain disorders. In addition, conditions which are rarely encountered in the hospital autopsy environment are seen in the setting of sudden death, particularly psychiatric cases, and cases related to addiction (drugs and alcohol).

科学研究的最终目的是改善公众的健康和福祉。为了实现这一点，我们需要了解疾病的机制，以便我们可以尝试开发新的治疗方法。神经系统疾病不仅对个人，而且对照顾者都造成相当大的痛苦。为了更好地理解疾病的过程，需要研究动物模型，试图找出疾病的机制，然后将这些机制转换到人类环境中。正是在这份翻译中，收集的人类材料，在尸检时获得的近亲的完全同意，是无价的。正是通过将组织捐赠给科学研究，一些照顾者才能安心，因为家庭成员的死亡可能会带来一些好处。多年来，从痴呆症和多发性硬化症等长期神经系统疾病的病例中收集脑组织，爱丁堡是国际公认的普里恩脑库中心。在猝死的背景下，由于死亡的意外，通常由于当事人年龄较小，丧亲之痛往往更加强烈，捐赠组织用于科学研究以前不是亲属可以选择的选项。MRC资助的爱丁堡大脑和组织银行提供了这个机会。虽然许多突然死亡的人在死亡时可能没有神经系统疾病，但与患有神经系统疾病的人的大脑相比，他们的组织可以提供有价值的信息。正常脑组织的这种控制功能对于研究所有的大脑疾病是必不可少的，并且与从大脑疾病中获取组织一样重要。此外，在医院尸检环境中很少遇到的情况出现在猝死的背景下，特别是精神病病例和与成瘾(毒品和酒精)有关的病例。