EAGER: Enabling Discovery and Scientific Collaboration on Human Memory via the Web-Based Atlas and Tissue Bank for Patient H.M.'s Brain

EAGER:通过基于网络的 H.M. 患者大脑图谱和组织库实现人类记忆的发现和科学合作

基本信息

  • 批准号:
    1663755
  • 负责人:
  • 金额:
    $ 30万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-22 至 2017-08-31
  • 项目状态:
    已结题

项目摘要

Knowledge of a specific neural network supporting memory function in the human brain stems from the case of patient H.M. who, in 1953 underwent an experimental medial temporal lobectomy in the hope of reducing the frequency and severity of his epileptic seizures. The operation was successful in that respect, but it unexpectedly left him incapable of creating new memories. For more than five decades, H.M. participated in hundreds of experiments and his case was discussed in thousands of scientific publications. His brain contained the clues to understand how memory works; however, determining with precision which structures were damaged was not possible because even the latest neuroimaging could not clearly resolve the anatomy of the temporal lobes. With support from the National Science Foundation, Dr. Jacopo Annese will complete an 'open source', web-based microscopic atlas of H.M.'s brain which was donated to science post-mortem. The tools-embedded atlas will support the creation of teaching curricula that will expose students to raw neuroimaging data from multiple modalities, cutting edge brain mapping algorithms, web-based exploration tools, all within the clinical and biographical context of H.M. as an individual. The cyber infrastructure created through this project is expected to enable discovery neuroscience by participants world wide. Specifically, Dr. Annese and his research team will (1) provide a dedicated support infrastructure to maintain and manage the web atlas for H.M.'s brain; (2) significantly increase the accuracy of the atlas by increasing the number of digitized histological slices to achieve 1 mm per slice interval (from 3mm interval); (3) acquire and deliver image stacks to enable remote quantitative studies; (4) implement new web tools to enable the handling of remote request and curation of results from different laboratories; (5) convert the images into formats that can be 3-D printed using consumer products. Such cyber infrastructure will make the valuable H.M. data available for new retrospective studies that may further change our current view of how memory is established in the human brain and enable quantitative analyses at the cellular level using a 'virtual microscope'. The resulting atlas will be used by researchers worldwide to re-interpret, based on clear anatomical evidence, the results from hundreds of neuropsychological exams conducted when H.M. was alive.
关于支持人类大脑记忆功能的特定神经网络的知识源于患者HM的案例他在1953年接受了一次实验性的内侧颞叶切除术,希望能减少癫痫发作的频率和严重程度。手术在这方面是成功的,但出乎意料的是,他无法创造新的记忆。五十多年来,H. M。他参与了数百项实验,他的案例在数千份科学出版物中进行了讨论。他的大脑包含了理解记忆如何运作的线索;然而,精确地确定哪些结构受损是不可能的,因为即使是最新的神经成像也无法清楚地解析颞叶的解剖结构。在美国国家科学基金会的支持下,Jacopo Annese博士将完成一个“开源”的、基于网络的H.M.死后捐献给科学研究的大脑嵌入工具的地图集将支持教学课程的创建,这些课程将使学生接触到来自多种模式的原始神经成像数据,尖端的大脑映射算法,基于网络的探索工具,所有这些都在H.M.的临床和传记背景下。作为一个个体。通过该项目创建的网络基础设施预计将使世界各地的参与者能够发现神经科学。 具体来说,Annese博士和他的研究团队将(1)提供专门的支持基础设施,以维护和管理H.M.的网络地图集。的大脑;(2)通过增加数字化组织切片的数量以实现每切片间隔1 mm,显著提高图谱的准确性(从3毫米间隔开始);(3)获取和提供图像堆栈,以便能够进行远程定量研究;(4)采用新的网络工具,以便能够处理来自不同实验室的远程请求和管理结果;(5)将图像转换为可以使用消费产品进行3D打印的格式。 这样的网络基础设施将使宝贵的H.M.这些数据可用于新的回顾性研究,这些研究可能会进一步改变我们目前对人类大脑中记忆是如何建立的看法,并使用“虚拟显微镜”在细胞水平上进行定量分析。 由此产生的图谱将被世界各地的研究人员使用,以明确的解剖学证据为基础,重新解释H.M.活着

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jacopo Annese其他文献

The visual cortex of man in standard anatomical space
  • DOI:
    10.1016/s1053-8119(00)91686-0
  • 发表时间:
    2000-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jacopo Annese;Georges Le Goualher;Alan Evans;Arthur Toga;Michael S. Gazzaniga
  • 通讯作者:
    Michael S. Gazzaniga
Brain Observatory and the Continuing Study of H.M.: Interview with Jacopo Annese
大脑观测站和 H.M. 的持续研究:Jacopo Annese 访谈
  • DOI:
    10.5964/ejop.v8i2.475
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Rhian Worth;Jacopo Annese
  • 通讯作者:
    Jacopo Annese

Jacopo Annese的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jacopo Annese', 18)}}的其他基金

EAGER: Enabling Discovery and Scientific Collaboration on Human Memory via the Web-Based Atlas and Tissue Bank for Patient H.M.'s Brain
EAGER:通过基于网络的 H.M. 患者大脑图谱和组织库实现人类记忆的发现和科学合作
  • 批准号:
    1442027
  • 财政年份:
    2014
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
SGER: Histopathological Examination of the Brain of the Amnesic Patient H.M.
SGER:失忆症患者大脑的组织病理学检查
  • 批准号:
    0714660
  • 财政年份:
    2007
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant

相似海外基金

Development of bile cell block specimens for enabling comprehensive genome profiling and therapeutic medicine discovery of bile tract cancer
开发胆细胞块样本,以实现胆道癌的全面基因组分析和治疗药物发现
  • 批准号:
    23K14646
  • 财政年份:
    2023
  • 资助金额:
    $ 30万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Enabling AI-based Mouse Genetic Discovery
实现基于人工智能的小鼠基因发现
  • 批准号:
    10724522
  • 财政年份:
    2023
  • 资助金额:
    $ 30万
  • 项目类别:
TBI-REPORTER (UK-TBI REpository and data PORTal Enabling discoveRy)
TBI-REPORTER(UK-TBI 存储库和数据门户支持发现)
  • 批准号:
    MR/Y008502/1
  • 财政年份:
    2023
  • 资助金额:
    $ 30万
  • 项目类别:
    Research Grant
Enabling antibiotics discovery by targeted protein degradation
通过靶向蛋白质降解实现抗生素发现
  • 批准号:
    2887360
  • 财政年份:
    2023
  • 资助金额:
    $ 30万
  • 项目类别:
    Studentship
CCRI: Research Infrastructure: NEW: Semantic Scholar Open Data Platform: Enabling Research Into Scientific Search and Discovery
CCRI:研究基础设施:新:语义学者开放数据平台:促进科学搜索和发现研究
  • 批准号:
    2213656
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Discovery and Development of Enabling Tools for the Synthesis and Late-Stage Modification of Natural Products and Pharmaceuticals
天然产物和药物合成和后期修饰的支持工具的发现和开发
  • 批准号:
    RGPIN-2019-06468
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:
    Discovery Grants Program - Individual
Enabling the Accelerated Discovery of Novel Chemical Probes by Integration of Crystallographic, Computational, and Synthetic Chemistry Approaches
通过整合晶体学、计算和合成化学方法,加速发现新型化学探针
  • 批准号:
    10398798
  • 财政年份:
    2021
  • 资助金额:
    $ 30万
  • 项目类别:
Enabling the Accelerated Discovery of Novel Chemical Probes by Integration of Crystallographic, Computational, and Synthetic Chemistry Approaches
通过整合晶体学、计算和合成化学方法,加速新型化学探针的发现
  • 批准号:
    10613499
  • 财政年份:
    2021
  • 资助金额:
    $ 30万
  • 项目类别:
Discovery and Development of Enabling Tools for the Synthesis and Late-Stage Modification of Natural Products and Pharmaceuticals
天然产物和药物合成和后期修饰的支持工具的发现和开发
  • 批准号:
    RGPIN-2019-06468
  • 财政年份:
    2021
  • 资助金额:
    $ 30万
  • 项目类别:
    Discovery Grants Program - Individual
CyberTraining: Implementation: Small: Enabling Dark Matter Discovery through Collaborative Cybertraining
网络培训:实施:小型:通过协作网络培训实现暗物质发现
  • 批准号:
    2017760
  • 财政年份:
    2020
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了