BIOMATERIALS PHD TRAINING FOR DENTISTS -- UMKC

本申请是对RFA DE-95-007的回应， 培训补助金T32 DE 07233 -01。该机构的总体目标是 研究服务奖是准备牙医的职业生涯在生物材料 研究和学术。重点是培训至少两名 临床研究方法的八名候选人。具体而言是 该计划的目标是准备学员：1）使用科学的 方法通过适当的课程，赠款申请，并监督 研究; 2）有助于牙科专业，科学 通过基础科学和临床研究为社区和公众提供服务;以及 3)在牙科学校、研究机构中担任学术和/或领导职务 中心或牙科相关行业。 培训中的学生 该计划将在一个渐进的研究环境中进行教育 由一个名为“改进聚合物”的计划项目赠款补充 通过分子设计的修复剂”（NIDR DE 09696，PI：J.D. Eick）。 该项目赠款目前已进入第五个资助年度。 招生活动将是全国范围和特殊的 将努力吸引妇女和少数民族学生。较5 一年的补助金期间，八名学生将被选中，并将完成 博士通过跨学科的博士课程。该计划， 本提案中概述的时间为三年（至少65 小时），并由一个重要的监督研究工作，沿着 28小时的必修或选修课程，如牙科 生物材料，研究设计，临床研究方法学，统计学， 生物化学、组织学和病理学。主 教学工作将在口腔生物学（牙科生物材料）和 学生将选择集中从一个次要领域， 以下领域：1）聚合物化学，2）表面化学，3）表面 物理学，4）材料科学与工程，以及5）毒理学。的 教员包括项目主任和十一名博士教员。 材料技术和分析在宽光谱中的应用 牙科生物材料使用和应用中的基本问题 提供了研究经验的基本主题。主要 研究经验的重点是界定形成， 相容性，结构，性质和行为的天然和 合成的修复和替代生物材料， 口腔两名博士后将致力于 特别是临床研究。临床研究 这些学员可获得的经验包括人类研究， 牙科生物材料的生物相容性/毒理学;固定修复 临床研究;使用新型无收缩粘合剂的体内研究 复合系统;以及儿童汞毒性研究。

This application is in response to RFA DE-95-007 and a resubmission of training grant T32DE07233-01. The overall goal of this institutional Research Service Award is to prepare dentists for careers in biomaterials research and academics. Emphasis has been added to train at least two of the eight candidates in clinical research methods. Specifically, the goals of the program are to prepare trainees to: 1) use the scientific method through appropriate coursework, grant applications, and supervised research; 2) contribute to the dental profession, the scientific community and the public through basic science and clinical research; and 3) hold academic and/or leadership positions in dental schools, research centers, or dental related industry. The students in the training program will be educated in a progressive research environment complemented by a program project grant titled "Improved Polymeric Restoratives Through Molecular Design" (NIDR DE09696, PI: J.D. Eick). This program project grant is currently in its fifth year of funding. Student recruitment activities will be national in scope and special efforts will be made to attract women and minority students. Over the 5 year grant period, eight students will be selected and will complete a Ph.D. through the interdisciplinary doctoral program. The program, outlined in this proposal, is three years in length (a minimum of 65 hours) and is composed of a significant supervised research effort along with 28 hours of required or selective courses in such areas as dental biomaterials, research design, clinical research methodology, statistics, grantsmanship, biochemistry, histology, and pathology. The primary didactic effort will be in oral biology (dental biomaterials) and the student will select a secondary area of concentration from one of the following areas: 1) polymer chemistry, 2) surface chemistry, 3) surface physics, 4) materials science and engineering, and 5) toxicology. The faculty members include the Program Director and eleven doctoral faculty. The application of material techniques and analyses to a broad spectrum of fundamental problems in the use and application of dental biomaterials provides the underlying theme for the research experience. The major focus of the research experience is related to defining the formation, compatibility, structure, properties, and behavior of natural and synthetic restorative and replacement biomaterials for use within the oral cavity. Two of the postdoctoral trainees will devote their efforts specifically to clinical investigations. The clinical research experiences available to these trainees include human studies involving the biocompatibility/toxicology of dental biomaterials; fixed restorative clinical research; in vivo research with new non-shrinking adhesive composite systems; and Hg toxicity studies in children.