ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT

描述：这是罗切斯特大学牙科研究和生物化学教授Lawrence Tabak博士指导的NRSA培训计划的更新申请。该计划的主要目标是为追求学术牙科职业的个人提供细胞和分子生物学的研究培训。这一目标将通过以下培训来实现：1)攻读博士学位的牙医；2)牙科-日期发布：攻读博士后水平研究培训的博士；3)攻读博士学位的学士；4)攻读细胞和分子生物学领域博士后研究培训的博士。受训者将根据他们的学习成绩、前任导师的推荐以及他们对口腔科学学术生涯的承诺来选择。将作出特别努力，征聘和培训人数不足的少数民族。寻求博士学位的学生将通过大学的生物和医学多学科计划入学，并将由指导委员会决定。入学后，将通过生物化学系、生物学系、生物物理系、牙科研究系、微生物学与免疫学系、神经生物学与解剖学系、病理学系、药理学系、生理学系和毒理学系为学员提供许多教学课程。博士研究生必须学习核心课程和与其研究领域相关的其他额外课程。核心课程包括研究轮转、研究伦理、牙科研究研讨会、普通生物化学、发育生物学、细胞器结构与功能、高级生物化学。经过三次实验室轮转（如有必要，四次轮转），学生将从参与研究的教师中选择一名导师，该导师在1)基因调控，2)细胞信号转导，3)大分子结构和功能关系，或4)细胞发育生物学等领域进行积极的研究。博士候选人也将选择一个“家庭部门”。将成立论文指导委员会，监督学生的研究进展。具有博士学位的受训者在进行实验室轮岗后也将被分配到参与的学院之一。细胞和分子生物学教学课程的需要将根据个人情况而定。每年招收博士后3人，博士预科3人，项目期间稳定保持6 - 8人。

DESCRIPTION: This is a renewal application for a NRSA training program directed by Dr. Lawrence Tabak, Professor of Dental Research and Biochemistry at the University of Rochester. The main objective of this program is to provide research training in cellular and molecular biology to individuals pursuing careers in academic dentistry. This objective will be accomplished by training: 1) dentists who are candidates for the PhD degree, 2) dentist-Date Released: PhDs pursuing postdoctoral level research training, 3) baccalaureate degree- holders pursuing the PhD, and 4) PhDs pursuing postdoctoral research training in the field of cell and molecular biology. Trainees will be selected on the basis of their academic records, recommendations of previous supervisors, and their commitment to academic careers in oral science. Special efforts will be made to recruit and train underrepresented minorities. Admission for students seeking the PhD degree will be through the university multi-disciplinary Program in Biology and Medicine, and will be determined by a Steering Committee. After admission, many didactic courses will be offered to trainees through the Departments of Biochemistry, Biology, Biophysics, Dental Research, Microbiology and Immunology, Neurobiology and Anatomy, Pathology, Pharmacology, Physiology, and Toxicology. PhD candidates must take the core courses and other additional courses related to their research areas. The core courses include research rotations, ethics in research, dental research seminar, general biochemistry, developmental biology, structure and function of cellular organelles, and advanced biochemistry. After three laboratory rotations (if necessary, four rotations), students will choose a mentor from the participating faculty who are actively conducting research in the field of 1) gene regulation, 2) cellular signal transduction, 3) structure and function relationships of macromolecules, or 4) cellular developmental biology. The PhD candidates will also choose a "home department." A thesis guidance committee will be formed to monitor students' research progress. Trainees with a PhD degree will also be assigned to one of the participating faculty after engaging in laboratory rotations. The need for didactic courses in cell and molecular biology will be determined on an individual basis. Three postdoctoral and three predoctoral trainees will be accepted per year to steadily maintain six to eight trainees throughout the project period.