MATCHING PATIENTS TO ALCOHOLISM TREATMENTS

申请人摘要： 本研究的总体目标是测试 “匹配假设”，酒精治疗的有效性可以 通过将具有某些特征的客户分配给 特殊治疗。本申请提出继续工作， 在过去五年中发起和开展的活动。的具体目标 研究内容是：检验初级和次级先验匹配 假设在15个月的随访过程中;进行 对患者、治疗过程和 结果变量来测试这些匹配的假设;检查 用于测试匹配的替代分析策略和变量;以及 以确定匹配效应在三个 治疗结束后一年。 从项目MATCH门诊患者（N=954）和 将对试验的术后护理（N=774）组进行分析，以实现这些 目标。 客户被随机分配到三个治疗之一，12 步骤，认知行为，或动机增强。他们 治疗前评估基线和匹配变量， 从治疗分配开始，每隔3个月随访15个月 来衡量他们的酒精消费量和其他方面的结果。 为了测试长期匹配效果的门诊病人， 将在治疗后39个月联系研究并进行评估 入会仪式 预计研究结果将影响酒精治疗 未来十年的研究和交付。 项目匹配指导委员会，在与NIAAA讨论后 工作人员选择在每个CRU中提交一份通用提案， 反映了共同的协议和合作进程， 该项目在其运作的前五年。但是，每个CRU 已在预算、预算中提供了特定于地点的信息 理由、关键人员名单、协商/联合体 协议，以及各自提案中的人类主题部分。

APPLICANT'S ABSTRACT: The overall aim of this study is to test the "matching hypothesis" that alcohol treatment effectiveness can be increased by assigning clients with certain characteristics to particular treatments. The present application proposes to continue work initiated and conducted over the past five years. The specific aims of the study are: to test primary and secondary a priori matching hypotheses over the course of 15 months of follow-up; to conduct psychometric and other analyses of patient, treatment process, and outcome variables to test these matching hypotheses; to examine alternative analytic strategies and variables for testing matching; and to determine the extent to which matching effects persist over a three year period following treatment completion. Data sets collected form the Project MATCH outpatient (N=954) and aftercare (N=774) arm of the trial will be analyzed top achieve these aims. Clients were randomly assigned to one of three treatments, Twelve Step, Cognitive Behavioral, or Motivational Enhancement. They were assessed prior to treatment on baseline and matching variables and followed, at 3 month intervals, for 15 months from treatment assignment to measure their alcohol consumption and other dimensions of outcome. To test longer term matching effects clients in the outpatient arm of the study will be contacted and assessed at 39 months after treatment initiation. It is anticipated that study results will impact on alcohol treatment research and delivery for the next decade. The Project MATCH Steering Committee, following discussion with NIAAA Staff, has chosen to submit a generic proposal across each of the CRUs, reflecting the common protocol and cooperative process that has guided the project across its first five years of operation. However, each CRU has provided site-specific information in the budget, budget justification, listing of key personnel, consultation/consortium agreements, and human subjects sections of their respective proposals.