Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

饮酒和吸烟同时治疗：对酒精复吸风险的影响

• 批准号: 7900076
• 负责人: NED L COONEY
• 金额: $ 43.52万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900076
• 关键词: Abstinence; Address; Affect; Alcohol abuse; Alcohols; Behavior Therapy; Behavioral; Cigarette; Cigarette Smoker; Clinical; Clinical Trials; Cognitive; Control Groups; Cues; Development; Early treatment; Enrollment; Environment; Expectancy; Exposure to; Future; Individual; Intervention; Measures; Motivation; Outcome; Outcome Study; Outpatients; Participant; Patients; Pharmaceutical Preparations; Placebos; Process; Process Assessment; Process Measure; Randomized; Recovery; Recruitment Activity; Relapse; Reporting; Research; Risk; Schedule; Self Efficacy; Self-control as a personality trait; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Smoking Status; Study Section; Tail; Technology; Testing; Tobacco; Voice; Withholding Treatment; alcohol abstinence; alcohol abuse therapy; alcohol craving; alcohol relapse; base; cigarette smoking; contingency management; coping; craving; cue reactivity; design; drinking; efficacy testing; improved; nicotine gum; nicotine patch; open label; response; smoking cessation; smoking intervention; theories; treatment effect; treatment program

DESCRIPTION (provided by applicant): Most alcohol and drug treatment programs do not systematically address cigarette smoking during treatment. One obstacle is a concern that smoking cessation early in recovery might increase risk of drinking relapse. Research on concurrent smoking cessation and alcohol treatment has yielded inconsistent results with respect to the impact of smoking cessation on drinking outcome. One problem with these studies is that they did not induce high smoking abstinence rates, so they did not offer much opportunity for smoking abstinence to undermine (or improve) alcohol outcomes. Our research team has recently has been testing the efficacy of various smoking cessation interventions for use during alcohol treatment. We found much better smoking quit rates in one study that used frequent brief behavioral contacts combined with contingency management. A second study by our team found somewhat better alcohol outcomes after a smoking cessation treatment that used a combination of nicotine patch and nicotine gum. Based on this research we developed for the proposed study a smoking cessation intervention that combines the most effective features of our earlier interventions. We believe this new intervention approach provides an excellent platform to address questions about the impact of smoking cessation on risk of alcohol relapse. We also believe that more information about the process of concurrent alcohol-tobacco treatment is needed before launching another outcome study. Results of this proposed clinical process study will guide the development of future clinical trials of smoking cessation for individuals with alcohol problems. Participants will be recruited as they begin intensive outpatient alcohol treatment. A randomized, 2-group design will compare one group provided a concurrent smoking cessation (CSC) intervention consisting of frequent brief behavioral contacts combined with contingency management plus open label nicotine patch and gum with a deferred smoking cessation (DSC) intervention group scheduled to receive a smoking intervention three months later. Dependent variables are process assessments reflecting alcohol relapse risk obtained using daily Interactive Voice Response (IVR) technology. These relapse risk processes include alcohol craving, negative affect, alcohol abstinence self efficacy, alcohol outcome expectancies, motivation for alcohol abstinence, and self-control demands. We will test the hypothesis that concurrent smoking cessation will have an impact on these process measures when compared with the deferred treatment control group. We will also follow our treated patients across three months using daily IVR process assessments in order to determine antecedents for relapse to drinking and test for differences between cigarette abstinent and smoking participants in identified drinking relapse antecedents. This study will allow tests of several competing behavioral theories of alcohol-tobacco interaction including cross substance cue reactivity theory, cross substance coping theory and limited strength theory.

描述（由申请人提供）：大多数酒精和药物治疗计划在治疗期间没有系统地解决吸烟问题。其中一个障碍是，人们担心在恢复早期戒烟可能会增加饮酒复发的风险。关于同时戒烟和酒精治疗的研究在戒烟对饮酒结果的影响方面产生了不一致的结果。这些研究的一个问题是，它们没有诱导高戒烟率，因此它们没有提供太多机会让戒烟破坏（或改善）酒精结果。我们的研究团队最近一直在测试各种戒烟干预措施在酒精治疗期间的效果。我们发现戒烟 在一项研究中，使用频繁的短暂行为接触结合应急管理。我们团队的第二项研究发现，在使用尼古丁贴片和尼古丁口香糖组合的戒烟治疗后，酒精效果有所改善。基于这项研究，我们为拟议的研究开发了一种戒烟干预措施，结合了我们早期干预措施的最有效特征。我们相信，这种新的干预方法提供了一个很好的平台，以解决有关戒烟对酒精复发风险的影响的问题。我们还认为，在开展另一项结果研究之前，需要更多关于同时进行烟酒治疗过程的信息。这项拟议的临床过程研究的结果将指导未来酒精问题个人戒烟临床试验的发展。参与者将在他们开始强化门诊酒精治疗时招募。 一项随机化、2组设计将比较一组接受同步戒烟（CSC）干预（包括频繁的短暂行为接触结合应急管理加上开放标签尼古丁贴片和口香糖），另一组接受延迟戒烟（DSC）干预，计划在3个月后接受吸烟干预。因变量是使用日常交互式语音应答（IVR）技术获得的反映酒精复发风险的过程评估。这些复发风险过程包括酒精渴望，负面影响，酒精戒断自我效能，酒精结果预期，酒精戒断的动机和自我控制的要求。我们将检验这一假设，即与延迟治疗对照组相比，同时戒烟将对这些过程测量产生影响。我们还将使用每日IVR过程评估对我们治疗的患者进行为期三个月的随访，以确定饮酒复发的前因，并测试戒烟和吸烟参与者在确定的饮酒复发前因中的差异。这项研究将允许测试几个竞争的行为理论的酒精-烟草相互作用，包括跨物质线索反应理论，跨物质应对理论和有限的力量理论。