1997 GORDON CONFERENCE ON ELASTIN AND ELASTIC TISSUE

描述（根据申请人的摘要和具体目标改编）： 申请寻求资金支持第十届戈登会议， 弹性蛋白和弹性组织将在梅里登的金博尔联合学院举行， 新罕布什尔州，1997年7月20日至25日。 弹性蛋白是一种主要的结构蛋白 的身体，提供延展性和弹性回缩的组织， 微纤维是不同糖蛋白的聚合物。 因为它对人体的生理和 许多组织的功能，弹性蛋白和微纤维基因的改变， 合成、组装和修复导致或与几个 具有重大社会意义的疾病，包括马凡氏综合征， 动脉瘤，肺气肿，肺和全身性高血压，动脉硬化， 以及许多皮肤病，如弹性组织变性和皮肤拉克萨。 的 会议将整合分子和细胞的新信息， 这些蛋白质的生物学，重点是针对定义 这些矩阵组件的功能和相互作用。 拟议 会议将汇集来自不同领域的基础科学家， 学科介绍和讨论弹性蛋白的最新信息 和微纤维蛋白。 与往年一样，这些互动将导致 在新的合作研究中， 这些重要的结缔组织蛋白质。

DESCRIPTION (Adapted from applicant's abstract and specific aims): This application seeks funding for support of the Tenth Gordon Conference on Elastin and Elastic Tissue to be held at Kimball Union Academy in Meriden, New Hampshire, from July 20-25, 1997. Elastin is a major structural protein of the body, providing extensibility and elastic recoil to the tissues in which it is found. Microfibrils are polymers of distinct glycoproteins. Because of the crucial contribution to the physical and physiological functions of many tissues, alterations in elastin and microfibrillar genes, synthesis, assembly, and repair lead to or are associated with several diseases of major social significance, including Marfan's Syndrome, aneurysms, emphysema, pulmonary and systemic hypertension, arteriosclerosis, and numerous skin conditions, such as elastosis and cutis laxa. The conference will integrate new information on the molecular and cellular biology of these proteins with an emphasis on studies directed at defining the function and interaction of these matrix components. The proposed meeting will bring together basic scientists from a variety of different disciplines to present and discuss the most recent information on elastin and microfibril proteins. As in past years, these interactions will result in new collaborative studies that stimulate novel avenues of investigation of these important connective tissue proteins.