CONFERENCE ON MOLECULAR BIOLOGY OF MUSCLE DEVELOPMENT

请求为Keystone研讨会“分子生物学”提供部分支持 肌肉发育“将在雪团会议中心举行， 科罗拉多州斯诺马斯，1997年4月1日至6日。这是第四届Keystone研讨会 研究骨骼肌生物学。肌肉发生机制研究的最新进展 塑造了科学家看待分化和发展的方式。这个 MyoD转录激活子家族的发现导致了 紧锣密鼓的调查和对导致细胞- 命运规范。决定早期发育的基因的上游 中胚层前体的命运正在被确定和表征。 对这种现象的基因分析对理解 这些调节因子的功能作用已经有了 不可预测的结果的数量。除了早期的活动之外 决定、细胞、分子和遗传方法已经开始 确定这些事件，如细胞-细胞相互作用和生长因子 在形成、多样化和功能中发挥作用的信号 肌肉的力量。细胞周期及其调节因子在肌肉中的作用 分化也开始阐明导致 差异化状态的建立和维护。分子 一些肌肉遗传性疾病的基础以及潜在的 我们将讨论如何治愈它们。这次会议旨在提供一种手段 将来自这些不同领域的调查人员聚集在一起，提供一个 肌肉生物学的多学科观点。会议将被组织起来 9次全体会议，3个促进交流和讨论的工作坊 和4次海报会议。在全体会议上，有好的方面 妇女和初级调查员的代表。大约350名外国 国内科学家将出席。与会者将从 从研究生到资深科学家。寻求财政支持以 根据以下方面的评估向学生和研究员颁发旅行奖学金 提交的摘要。

Partial support is requested for the Keystone Symposium "Molecular Biology of Muscle Development" to be held at the Snowmass Conference Center, Snowmass, Colorado, April 1-6, 1997. This is the fourth Keystone symposium on skeletal muscle biology. Recent advances in understanding myogenesis have shaped the way scientists view differentiation and development. The discovery of the MyoD family of transcriptional activators has led to intense investigation and insight into regulatory pathways leading to cell- fate specification. Genes far upstream in early development that determine the fate of mesoderm precursors are being identified and characterized. Genetic analysis of such has contributed a great deal toward understanding the functional roles of these regulatory factors and there have been a number of unpredicted outcomes. In addition to early events in determination, cell, molecular and genetic approaches haven begun to identify those events such as cell-cell interaction and growth factor signaling that play roles in the formation, diversification and function of muscle. The role of the cell cycle and its regulators in muscle differentiation has also begun to elucidate pathways leading to the establishment and maintenance of the differentiated state. The molecular basis for a number of genetic diseases of muscle as well as the potential to cure them will be discussed. This meeting is intended to provide a means of bringing together investigators from these diverse fields to provide a multidisciplinary view of muscle biology. The meeting will be organized into 9 plenary sessions, 3 workshops for promoting exchange and discussion and 4 poster sessions. In the plenary sessions, there is good representation of women and junior investigators. Approximately 350 foreign and domestic scientists will be in attendance. Attendees will range from graduate students to senior scientists. Financial support is sought to award travel fellowships to students and fellows based on evaluation of abstracts submitted.