THE HORMONAL CONTROL OF FETAL GROWTH

描述（改编自申请人摘要）：申请人 建议测量神经元的大小和数量的变化， 树突和轴突在他的转基因小鼠的TThC。 以确定 IGF-I影响神经发育的机制，他将 检查IGF-I对a）神经元细胞增殖的体内作用， 迁移，B）神经元凋亡，c）I型受体的调节 和d）可能介导这些变化的候选基因的表达 由IGF-I诱导。 IGFBPs的调节作用也将被研究 使用初级神经元研究。 最后，申请人将测试 假设IGF-I表达或作用的减少介导了 营养不良的大脑病理学 他预测IGF-I过表达 IGFBP-1的表达会加重营养不良 对TTHC的影响

DESCRIPTION (Adapted from the applicant's abstract): The applicant proposes to measure changes in the size and number of neurons and their dendrites and axons in the TThC in his transgenic mice. To determine the mechanisms by which IGF-I influences neural development, he will examine IGF-I's in vivo effects on a) neuronal cell proliferation and migration, b) neuronal apoptosis, c) the regulation of type I receptors and d) the expression of candidate genes that may mediate the changes induced by IGF-I. The modulatory effects of IGFBPs will also be studied using primary neuronal studies. Finally, the applicant will test the hypothesis that decreases in IGF-I expression or actions mediate the brain pathology of malnutrition. He predicts that IGF-I overexpression will ameliorate and IGFBP-1 expression will exacerbate malnutrition's effects on the TThC.