VOLTAGE GATED CARDIAC POTASSIUM CHANNELS

描述(改编自申请人的摘要)：该项目的长期目标 项目是了解心脏疾病的分子基础。 兴奋性，集中在分子结构-功能关系上 心肌K+通道。需要检验的假设是特定的区域 甚至特定的氨基酸残基也与激活和 去激活、门控和纠正心脏K通道。具体的 被调查的目的包括：(1)测试是否有 HKv1.5的细胞外带正电荷环是一个分子决定因素 向外整流，(2)检测第六跨膜是否 域(S6)包括激活门的一部分，该信息应该 加深对丹参的分子生理学和药理学的认识 心脏K通道和进一步帮助克隆的亚基与 天然心肌细胞的膜电流。最后，获得的信息 将扩大我们对这类重要的K的作用的认识 渠道，这最终可能导致对 心律失常的发生与抗心律失常药物的发展 探员们。

DESCRIPTION (Adapted from Applicant's abstract): The long term goal of this project is to gain an understanding of the molecular basis of cardiac excitability, concentrating on molecular structure-function relationships of cardiac K+ channels. The hypotheses to be tested are that specific regions and even specific amino acid residues are implicated in activation and deactivation gating and rectification of cardiac K channels. The specific aims to be investigated include: (1) test of whether or not an extracellular ring of positive charges in hKv1.5 is a molecular determinant of outward rectification, (2) test whether or not the sixth transmembrane domain (S6) comprises part of the activation gate, This information should advance our understanding of the molecular physiology and pharmacology of cardiac K channels and further help in correlating cloned subunits with membrane currents in native cardiac cells. Finally, the information gained will expand our knowledge of the function of this important class of K channels, which may ultimately result in improved understanding of the genesis of cardiac arrhythmias and the development of better antiarrhythmic agents.