FAMILY STUDY OF OBESSIVE COMPULSIVE DISORDER

这是一个有竞争力的续约申请， 强迫症的控制、直接访谈家庭研究 强迫症（OCD） 总体目标是采用家庭研究方法 探讨强迫症的遗传度及其与其他焦虑的关系 疾病和可能的病因异质性。 第一个供资期的调查结果表明， 强迫症的家族传播，不同于其他焦虑症。 然而，尽管有几个有希望的线索，样本量太小 为了有效地调查强迫症的可能异质性， 尊重家庭传播或其强迫性人格 疾病（OCP）。 在拟议的资助期内，主要目标是：1）进一步 通过以下方式评估我们最初发现的特定家族聚集性： 尝试在新收集的独立强迫症样本中进行复制， 控制家庭; 2）达到足够的样本量，以有效地 探讨强迫症可能的异质性及其与OC的关系 和OCP通过结合来自当前和拟议研究的OCD家族。 此外，为了开始调查可能的代际模式， 传播强迫症，隔离分析将进行测试， 我们的数据与几种传输模型的拟合（例如， 多因子、两个位点、回归）。 本研究的长期目标是增加对 强迫症的病因及其与其他焦虑症的关系。 提高认识将有助于制定更具体和 有效的治疗措施。

This is a competitive renewal application to continue a blind, controlled, direct interview family study of obsessive compulsive disorder (OCD). The overall objective is to use the family study method to investigate the heritability of OCD, its relationship to other anxiety disorders, and possible etiologic heterogeneity. Finding during the first funding period indicate moderate, specific familial transmission of OCD, distinct from other anxiety disorders. However, despite several promising leads, the sample size is too small to effectively investigate either the possible heterogeneity of OCD with respect to familial transmission or its obsessive compulsive personality disorder (OCP). The main objectives during the proposed funding period are to: 1) further evaluate our initial finding of specific familial aggregation by attempting replication in a newly collected independent sample of OCD and control families; and, 2) achieve sufficient sample size to effectively investigate the possible heterogeneity of OCD and its relationship to OC and OCP by combining OCD families from the current and proposed studies. In addition, to begin to investigate possible modes of intergenerational transmission of OCD, segregation analyses will be carried out to test the fit of our data with several models of transmission (e.g., multifactorial, two locus, regressive). The long term objectives of this study are to increase the understanding of the etiology of OCD and its relationship to other anxiety disorders. Improved understanding will enable development of more specific and effective treatment interventions.