Potency and activity of Meso-Endothelial bipotent progenitors in vivo

该项目旨在描述一种新的干细胞群，这种干细胞群既能维持血管，又能促进纤维、骨骼、脂肪或软骨等多种组织的形成。血管由内层内皮和周围的间质组成，是许多器官不可或缺的一部分，构成了连接身体不同部位的独特系统。尽管它们很重要，但人们对它们是如何维持的以及它们是如何对损伤做出反应的知之甚少。先前的工作已经描述了几种能够自我更新和内皮或间质补充的干细胞群体。该项目将研究这些不同的祖细胞在体内平衡以及发声和骨形成过程中产生这些命运的效力。这将有助于定义一个独特的干细胞群体，既能修复血管，也能修复间充质。

This project aims to characterise a new stem cell population that can maintain both blood vessels and contribute to a variety of tissues whether fibrous, bone, fat or cartilage. Blood vessels comprise an inner endothelial layer and surrounding mesenchyme, are integral to many organs and constitute a unique system connecting different parts of the body. Despite their importance little is known about how they are maintained and how they contribute to the response to injury. Previous work has described several populations of stem cell capable of self renewal and repletion of the endothelium or the mesenchyme. This project will examine the potency of these different progenitors to give rise to each of these fates in homeostasis but also during sounding and bone formation. This will help define a unique population of stem cells capable of both vascular and mesenchymal repair.