PREFRONTAL CORTEX AND MEMORY PROCESSING

描述：(摘自摘要)当前的主要目的 建议是测试动物之间是否存在对应关系 在前额叶皮质对记忆功能的调节方面 并确定前额叶皮质的特定亚区 (例如，中央前内侧、扣带前、下缘和前缘， 背外侧额叶或中央前外侧，无颗粒岛状，和 腹内侧眶皮质)不同地调节特定的工作 不同属性的记忆功能以及中介更高的- 基于信息时间排序和配对的排序关系 助理学习。前额叶皮质大鼠的研究进展 损伤表明，大鼠的工作记忆也有困难 对于不同的属性，难以对特定属性进行时间排序 属性信息、学习困难与配对记忆 关联属性信息，此外，不同的子 地区可能会协调这些属性。为了进一步阐述 前额叶皮质不同亚区在调节中的作用 工作记忆，凯斯纳博士在 它可以测量：a)不仅是空间位置的工作记忆， 由特定位置的对象定义，但也包括工作记忆 对于异心空间距离(两个对象之间的距离)和 以自我为中心的空间距离(主客体之间的距离)为 以及独立于空间的视觉对象的工作记忆 位置，b)自我中心空间(运动，从右到左)的工作记忆 转向反应)c)影响的工作记忆，以大小衡量 D)用于存储订单信息的滞后函数 不仅用于空间位置列表，还用于可视位置列表 对象，e)对象-对象、对象-空间的学习和表现 位置和空间位置-空间位置配对关联 信息。凯斯纳博士建议将这种动物模型作为一种手段 继续研究前额叶皮质在脑内的作用 调节特定属性信息的工作记忆和更高的- 时序和配对相伴等有序助记过程 学习。

DESCRIPTION: (From the abstract) The primary purpose of the present proposal is to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function and to determine whether specific sub-regions of the prefrontal cortex (e.g., medial precentral, anterior cingulate, infralimbic and prelimbic, dorsolateral frontal or lateral precentral, agranular insular, and ventromedial orbital cortex) differentially mediate specific working memory functions for different attributes as well as mediate higher- order relationships based on temporal ordering of information and paired associate learning. Previous research in rats with prefrontal cortex lesions has suggested that rats also have difficulty in working memory for different attributes, difficulty in temporal ordering of specific attribute information, difficulty in learning and retention of paired associate attribute information and furthermore that different sub- regions may mediate these attributes. In order to elaborate further on the role of different sub-regions of the prefrontal cortex in mediating working memory, Dr. Kesner has developed a set of behavioral tasks in which one can measure: a) not only working memory for spatial location, as defined by an object in a specific location, but also working memory for allocentric spatial distance (distance between 2 objects) and egocentric spatial distance (distance between subject and object) as well as working memory for visual objects independent of spatial location, b) working memory for an egocentric spatial (motor, right-left turn response) c) working memory for affect as measured by magnitude of reinforcement, d) a lag function for memory for order information not only for a list of spatial locations, but also for a list of visual objects, e) learning and performance of object- object, object-spatial location and spatial location-spatial location paired associate information. Dr. Kesner proposes to use this animal model as a means of continuing the investigation of the role of the prefrontal cortex in mediating working memory for specific attribute information and higher- order mnemonic processes such as temporal order and paired associate learning.