TISSUE WATER MEASUREMENTS OF BRAIN EDEMA WITH MRI

描述：（申请人的摘要） 能够准确评估和量化大脑的水肿状态 由不同的病理条件引起的。 总的来说， 脑水肿的治疗方法需要了解这两个方面 颅内容积紊乱的位置和程度 体内平衡 目前缺乏一种敏感、可靠的手段， 非侵入性测量脑水是一个主要的障碍， 开发脑水肿及相关疾病的有效治疗方法 条件 在这个项目中，我们建议测试假设，一个三- 三维磁共振快速成像技术可用于 获取缺血性中风常见影响区域的含水量。 具体来说，我们将测试自旋密度是一个假设， 准确的方法来估计水含量。 这一假设将是 测试了不同病理状态的组织水。 的 与获得精确的自旋密度相关的困难将是 通过使用最先进的成像器的新的成像方法来处理。 选择缺血性脑水肿作为测试范例，因为我们的实验室 具有良好表征的动物模型的丰富经验， 缺血性中风 该模型的变体表现出不同的模式 有助于检查鉴别诊断 对自旋-晶格弛豫、自旋-自旋弛豫和自旋密度的影响 测量. 模拟尺寸和 人类大脑的异质性将被用来测试 该方法可用于未来的临床应用。

DESCRIPTION: (Applicant's Abstract) It is critically important to be able to accurately assess and quantify the edematous state of the brain that results from different pathological conditions. In general, therapeutic approaches to brain edema require an understanding of both the location and magnitude of disturbances in intracranial volume homeostasis. The present lack of a sensitive, reliable means of measuring brain water non-invasively is a major hindrance to the development of effective therapies for cerebral edema and associated conditions. In this project, we propose to test the hypothesis that a three- dimensional magnetic resonance fast imaging technique can be used to obtain water content in regions commonly affected by ischemic stroke. Specifically, we will test the hypothesis that the spin density is an accurate means to estimate the water content. This hypothesis will be tested on different pathological states of the tissue water. the difficulties associated with obtaining accurate spin density will be dealt with by novel imaging methods using a state-of-the-art imager. Ischemic brain edema is chosen as a test paradigm because our laboratory has extensive experience with a well characterized animal model of ischemic stroke. The variants of this model exhibit different patterns of edema formation that lend themselves to examining differential effects on spin-lattice relaxation, spin-spin relaxation and spin density measurements. A phantom study simulating the dimensions and heterogeneity of the human brain will be use to test the feasibility of this proposed method for future clinical applications.