THRIVE: a Development Project to produce a pre-production prototype of a new system to assist in the treatment of osteoporosis by the stimulation of muscle pumps to augment bone blood supply

除了心脏之外，身体还有肌肉泵，它们对身体周围血液的健康流动至关重要。这些泵位于腿部的主要肌肉，经常使用这些肌肉对健康的身体是必不可少的。天空医疗技术与玛丽皇后医院研究和开发了一种新的机电刺激技术，激活这些肌肉泵时，它是不可能的身体这样做自愿。这增加了体内的血流量，并已被证明对预防深静脉血栓形成（DVT）有临床效果。早期的研究也表明，使用这种技术对尿失禁和大便失禁等疾病具有治疗效果。我们建议继续进行由西北农业部资助的研究和发展项目的研究（见附录A）该项目证明OnPulse技术有能力改善骨髓中的血液灌注，从而防止骨髓炎的发生。骨质疏松这在脊髓损伤（SCI）患者的情况下尤其如此。SCI的受害者几乎肯定会遭受骨质疏松症的发作所带来的他们的irimmobilization。这导致受害者额外的痛苦，通过显着增加的可能性，严重和潜在的致命骨折，他们的手腕，椎骨和臀部。这个项目将提供和优化，预生产原型的神经刺激设备的研究和证明，在以前的赠款的研发项目。该项目还将在原有核心技术（为预防DVT而开发）的基础上生产新的IP。该开发计划将使Sky Medical Technology能够快速开发高度创新和颠覆性的技术，并为其投资者提供第二个IP产品。

The body has muscle pumps in addition to the heart that are vital in the healthy flow of bloodaround the body. These pumps are located in the major muscles of the legs and regular use ofthese muscles is essential for a healthy body. Sky Medical Technology with Queen MaryHospital has researched and developed a novel electro-mechanical stimulation technology thatactivates these muscle pumps when it is not possible for the body to do so voluntarily. Thisincreases blood flow in the body and has been shown to have a clinical effect on theprevention of deep vein thrombosis (DVT). There are also indications from early work thatuse of this technology has a therapeutic effect on conditions such as urinary and faecalincontinence.We propose to continue the work conducted in an NWDA funded Grant for Research andDevelopment project (see Appendix A) that investigated the feasibility of using a novel Thisproject demonstrated that the OnPulse technology has the ability to improve blood perfusionin the bone marrow thus preventing the onset of osteoporosis. This was shown to beparticularly true in the case that the subject was a victim of spinal cord injury (SCI). SCIvictims are almost certain to suffer the onset of osteoporosis brought on by theirimmobilisation. This causes the victim additional suffering through the significantlyincreased likelihood of serious and potentially fatal fractures to their wrists, vertebrae andhips.This project will deliver and optimised, pre-production prototype of nerve stimulationequipment researched and proven in the previous Grant for R&D project. This project willalso produce new IP based on the original core technology (developed to prevent DVT). Thisdevelopment programme will enable Sky Medical Technology to rapidly develop a highlyinnovative and disruptive technology and offer a second IP offering to its investors.