NATURAL HISTORY OF ARTHRITIS AND RHEUMATISM ON THE GILA RIVER INDIAN COMMUNITY

骨关节病、类风湿性关节炎的发生和发展 关节炎和强直性脊柱炎是通过 进行了临床、放射学和血清学检查 在吉拉河的成年人中， 亚利桑那州的印第安人社区（皮马印第安人）， 糖尿病的流行病学研究。 的 本研究的目的是确定 这些疾病在人群中，并确定因素， 易患或改变疾病进展的自然史 疾病 宿主因素如年龄、性别和各种基因标记 包括HLA和Gm，以及各种潜在的环境 决定因素，如肥胖和接触传染性疾病的证据， 代理商，正在进行前瞻性调查，以确定他们的 与这些疾病的发展有关。 纵向数据 已经收集了25年，代表了一个独特的数据集， 用于关节炎的流行病学研究。 最近的分析表明， 研究了皮马人髋关节骨关节炎的患病率 这比美国的一般人口要多一些。 与髋关节骨关节炎的发展有关的因素是 正在接受检查。

The development and progression of osteoarthrosis, rheumatoid arthritis and ankylosing spondylitis are being determined by means of clinical, radiographic and serological examinations carried out prospectively at two-yearly intervals among adults of the Gila River Indian Community (Pima Indians) in Arizona, in conjunction with epidemiological studies of diabetes in the same community. The purpose of this investigation is to ascertain the determinants of these diseases in the population, and to identify factors which predispose to or alter the natural history of progression of the disease. Host factors such as age, sex, and various gene markers including HLA and Gm, together with various potential environmental determinants, such as obesity and evidence of exposure to infectious agents, are being investigated prospectively to determine their relationship to the development of these diseases. Longitudinal data have now been collected for 25 years and represent a unique data set for epidemiological studies of arthritis. Recent analyses have examined the prevalence of hip osteoarthritis in the Pima population which is some what greater than in the general U.S. population. Factors relating to the development of osteoarthritis of the hip are being examined.