HIV IN INJECTION DRUG USERS

注射吸毒是艾滋病毒日益普遍的辅助因素 在美国的传播，导致增加率 传染给异性伴侣， 母婴传播 在本财年，模型系统的研究 完成了注射器消毒， 遗传物质经过有经验的 药物滥用研究志愿者注射吸毒者（IDU志愿者）。 在分析来自活跃人群的病毒载量研究数据时- 自我管理IDU志愿者，高水平的循环HIV-1， 在外周白色血细胞和血浆中检测到。 比较 检测技术显示，HIV捕获/PCR显示最大的 检测HIV-1的敏感性。这些研究正在 并辅以艾滋病毒感染者的药物奖励研究 痴呆/脑病目前处于计划阶段。

Injection drug use is an increasingly-prevalent cofactor for HIV transmission in the United States, leading to increased rates of transmission into the heterosexual partners and marked increases in maternal-fetal transmission. During this FY, studies of model systems for syringe disinfection were completed that reveal persistance of HIV genetic material after syringe-washing procedures employed by experienced drug abusing research volunteer injection drug users (IDU volunteers). In analyzing data from viral load studies from a population of actively- self-administering IDU volunteers, high levels of circulating HIV-1 were detected in peripheral white blood cells and in plasma. Comparisons of detection techniques revealed that HIV capture/PCR displayed maximal sensitivity for detecting HIV-1 in the IDUs. These studies are being supplemented by studies of drug reward in individuals with HIV dementia/encephalopathy currently in planning stages.