MUTATIONS IN THE HPRT GENE, SMOKING AND LUNG CANCER

致癌物诱导靶组织中癌症相关基因突变 例如支气管上皮细胞被认为是 致癌作用由于检测到靶基因中的大多数基因突变， 组织是不实际的，替代基因，这可能表明关键的 体细胞突变将提供对癌症相关诱变的深入了解。 次黄嘌呤磷酸核糖转移酶基因是一个很好的替代基因 基因的研究，因为HPRT突变体是一种可选择的表型， 代表广义体细胞突变的标记。

Carcinogen-induced mutations to cancer-related genes in target tissues such as bronchial epithelium are thought to be a major mechanism of carcinogenesis. Since detection of mutations in most genes in target tissues is not practical,a surrogate gene which could indicate critical somatic mutations would provide insight into cancer-related mutagenesis. The hypoxanthine phosphoribosyl transferase gene is a good surrogate gene for study,since HPRT mutants are a selectable phenotype which represent a marker for generalized somatic mutation.