课题基金 / 基金详情

GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION

GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
调节髓磷脂基因表达的遗传元件
批准号：
2616636
负责人：
ANTHONY T CAMPAGNONI
金额：
$24.06万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-07-01 至 2002-05-31
来源：
https://reporter.nih.gov/project-details/2616636
关键词：
RNA splicing animal genetic material tag cell differentiation developmental genetics developmental neurobiology gene induction /repression gene mutation genetic promoter element genetic regulatory element genetic transcription genetically modified animals laboratory mouse myelin basic proteins myelination neurogenetics oligodendroglia recombinant proteins reporter genes structural genes tissue /cell culture

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项目成果

ANTHONY T CAMPAGNONI的其他基金

相关文献

中文摘要
翻译
描述：Golli-mbp基因编码两个蛋白质家族， 蛋白质和髓鞘碱性蛋白质。 这个项目的总体目标是 应用是确定基因调控元件， 特异性调节转录起始位点的基因， 神经系统和巨噬细胞中的少突胶质细胞和神经元， 免疫系统中的其他细胞。 此应用程序的一部分是使用 启动子元件，以及表达报告基因的转基因小鼠 在它的控制下，研究这些皮层的发育生物学， 先驱神经元和它们形成的亚板的命运。
英文摘要
DESCRIPTION: The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins. The overall goal of this application is to identify the genetic regulatory elements that govern specificity in the regulation of transcription start sites for this gene in oligodendrocytes and neurons in the nervous system and in macrophages and other cells in the immune system. A part of this application is to use a promoter element, as well as transgenic mice expressing a reporter gene under its control to investigate the developmental biology of these cortical pioneer neurons and the fate of the subplate that they form.
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CORE--MOLECULAR BIOLOGY
CORE--MOLECULAR BIOLOGY
Golli-MBP Gene Expression in the Nervous System
Golli-MBP Gene Expression in the Nervous System