MODIFICATION OF BLOOD FLOW FOR IMPROVED TUMOR THERAPY

这项建议的目的是评估是否在血液流动的变化， 对血管活性剂的反应可用于预测肿瘤的变化 在施用药剂后对辐射的反应。 的 结果将有深远的影响，如果一个人可以确定之前， 肿瘤对放射的血管活性改变有反应的疗法 治疗 一种很有前途的核磁共振灌注成像（NMR-PI）技术将用于 测量肿瘤灌注分布的变化， 烟酰胺和41 ℃温和加热1小时） 肿瘤的 该提案的具体目标是： 1)为了获得给药前和给药后的NMR灌注图像， 烟酰胺在几种肿瘤模型中的作用， 血管对烟酰胺的反应。 2)在给药前后扩展NMR-PI测量 温和加热，含或不含烟酰胺。 3)获得自发性肿瘤治疗前后的NMR灌注图像， 烟酰胺或烟酰胺/轻度加热的给药。 肿瘤 由基因工程产生的转基因小鼠将用于这一研究。 study. 4)为了确定所用肿瘤模型中的NMR-PI平均值是否 与相同模型中的肿瘤血流测量相比， 使用更广泛接受的方法。 NMR灌注测量 将大鼠和小鼠肿瘤模型中的平均值与 分别来自放射性微球和铷摄取。 5)确定肿瘤放射反应的改变， 在自发性肿瘤模型中给予烟酰胺/轻度加热。 为了确定同一动物的血流参数的变化 由于给予烟酰胺/轻度发热。

The goal of this proposal is to assess whether a change in blood flow in response to a vasoactive agent can be used to predict changes in tumor response to radiation following the administration of the agent. The results will have profound implications if one could determine before therapy which tumors will respond to vasoactive modification of radiation treatment. A promising NMR perfusion imaging (NMR-PI) technique will be used to measure changes in tumor perfusion distribution in response to nicotinamide and mild heat 41 degrees C for 1 hour) in models of human tumors. The specific aims of the proposal are: 1) To obtain NMR perfusion images before and after the administration of nicotinamide in several tumor models that are expected to span the range of vascular responses to nicotinamide. 2) To extend NMR-PI measurements before and after the administration of mild heat with and without nicotinamide. 3) To obtain NMR perfusion images in spontaneous tumors before and after the administration of nicotinamide or nicotinamide/mild heat. Tumors arising from genetically engineered, transgenic mice will be used in this study. 4) To determine whether NMR-PI mean values in the tumor models employed compare favorably with measurements of tumor blood flow in the same model systems using more widely-accepted methods. NMR perfusion measurements in rat and mouse tumor models will be compared with the average value from radioactive microspheres and rubidium uptake, respectively. 5) To determine the modification in tumor radiation response following the administration of nicotinamide/mild heat in spontaneous tumor models. And to determine in the same animals the change in a blood flow parameter due to the administration of nicotinamide/mild heat.