ASPECTS OF UTERINE RECEPTIVITY FOR IMPLANTATION

描述：(根据申请者的描述改编)调查人员 建议进一步研究前列腺素(PGs)在 环氧合酶(COX-1和COX-2)在子宫不同时期的表达 使用COX-1或COX-2基因突变的小鼠的感受性。他们还计划 为了研究白三烯(LT)是否单独或与PG一起在 植入。具体目的是为了检查：(1)表达 COX-1、COX-2及前列腺素在围植入期子宫中的表达 野生型、杂合子或纯合子小鼠的COX-2和COX-1基因突变 基因：(2)PG受体的表达；(3)(COX) 围植入期子宫组织中5-脂氧合酶(5-LO)和LTS水平的变化 这些小鼠以及(4)PGs/LTS在获得子宫中的作用 对植入的接受性。

DESCRIPTION: (Adapted from Applicant's Description) The investigators propose to examine further the roles of Prostaglandins (PGs) catalyzed by cyclooxygenases (COX-1 and COX-2) during various phases of uterine receptivity using mice mutated for the COX-1 or COX-2 gene. They also plan to examine whether leukotrienes (LTs) alone or with PGs play any roles in implantation. The specific aims are to examine: (1) the expression of COX-1 and COX-2, and levels of PGs in the periimplantation uteri of wild-type, heterozygous or homozygous mice mutated for the COX-2 and COX-1 genes, respectively, (2) the expression of PG receptors, and (3) of (COX) 5-lipoxygenase (5-LO) and levels of LTs in the periimplantation uteri of these mice, as well as (4) role of PGs/LTs in the attainment of uterine receptivity for implantation.