CONTROL OF ETHANOL INGESTION BY CONDITIONED REINFORCERS

条件性增强子(CSR)被认为与药物调节有关。 强化的行为。条件性增强剂与增强剂的关系 酒精摄入量还没有得到广泛的研究。有证据表明 乙醇相关的中性刺激可以获得增强的特性。 乙醇和CSR都受中脑边缘多巴胺系统的影响。它 假设通过将中性刺激与社会责任相匹配而产生的企业社会责任 口服乙醇自我给药将同时影响启动和 维持一场酒精大战和中脑边缘多巴胺系统 调节两种增强剂的功效。这一假设将是 使用操作技术检查以评估(1)口腔自我保护能力 管理乙醇以建立企业社会责任，(2)企业社会责任在 启动和维持乙醇消费，以及(3)调节 中脑边缘多巴胺在乙醇和CSR增强中的作用。条件性的 增援将根据中性刺激的维持能力进行评估 在生物灭绝期间做出反应。应答率的变化 企业社会责任的存在和缺席将被用来评估其在 启动和维持乙醇自我给药。微量注射 在物种灭绝之前将安非他明注入伏隔核 将被用来评估中脑边缘多巴胺在这些过程中的作用。 研究CSR在乙醇强化中的作用将提供见解 他们对维持过量乙醇消费的贡献 然后释放。

Conditioned reinforcers (CSR) have been implicated in modulating drug- reinforced behaviors. The relationship between conditioned reinforcers and ethanol intake has not been extensively studied. Evidence suggests that ethanol-associated neutral stimuli can acquire reinforcing properties. Ethanol and CSR are both influenced by the mesolimbic dopamine system. It is hypothesized that a CSR generated by pairing a neutral stimulus with oral ethanol self-administration will influence both the initiation and maintenance oa an ethanol bout and the mesolimbic dopamine system will modulate the efficacy of both reinforcers. This hypothesis will be examined using operant techniques to asses (1) the ability of orally self- administered ethanol to establish a CSR, (2) the role of the CSR in the initiation and maintenance of ethanol consumption, and (3) the modulatory role of mesolimbic dopamine in ethanol and CSR reinforcement. Conditioned reinforcement will be assessed by the neutral stimuli's ability to maintain responding during operant extinction. Alterations in response rate ina the presence and absence of the CSR will be used to assess its role in initiation and maintenance of ethanol self-administration. Microinjection of amphetamine into the nucleus accumbens prior to an extinction session will be used to assess the role of mesolimbic dopamine in these processes. Examining the role of CSR in ethanol reinforcement will provide insight into their contribution to the maintenance of excessive ethanol consumption and release.