CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES

我们正在进行一系列涉及患者的临床调查 与系统性红斑狼疮有关的问题 对发病机制、流行病学、治疗和并存进行了讨论。 正在进行的治疗研究包括一项长期的随机试验 糖皮质激素和免疫抑制药在重症、慢性阻塞性肺疾病患者中的应用 增殖性狼疮肾小球肾炎与核苷I/II期 狼疮患者中类似的2-氯脱氧腺苷和DNA酶 肾炎。正在进行研究，以评估与以下疾病相关的风险因素 骨质疏松症和血管血栓事件的发展。 与对狼疮发病机制感兴趣的科学家合作研究 在过去的一年里，包括了细胞因子对 自身免疫(D.Klinman)，与染色质结合的抗体与 肾小球基底膜的胶原蛋白(J.B.Lefkowith)，以及 FcGammaRIIa等位基因是非裔美国人肾炎的危险因素 (J.E.三文鱼)

We are conducting a series of clinical investigations involving patients with systemic lupus erythematosus in which questions related to disease pathogenesis, epidemiology, therapy and co-morbidities are addressed. Therapeutic studies in progress include a long-term, randomized trial of corticosteroids and immunosuppressive drugs in patients with severe, proliferative lupus glomeruonephritis and phase I/II of the nucleoside analog 2-chlorodeoxyadenosine and DNASE similarly in patients with lupus nephritis. Studies are underway to assess risk factors associated with the development of osteoporosis and vascular thrombotic events. Collaborative studies with scientists interested in lupus pathogenesis during the past year have included the influences of cytokines in autoimmunity (D. Klinman), antibody binding to chromatin adherent to the collagen of the glomerular basement membrane (J.B. Lefkowith), and FcgammaRIIa alleles as risk factors for nephritis in African-Americans (J.E. Salmon).