mRNA编辑蛋白--人类基因表达的转录后调控-猫眼课题宝

mRNA编辑蛋白--人类基因表达的转录后调控

批准号：

2568990

负责人：

A P PATTERSON

金额：

$0.0万

依托单位：

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2568990

关键词：

amination aminohydrolases apolipoproteins cytidine enzyme biosynthesis enzyme complex gene expression human genetic material tag human tissue messenger RNA nucleotides phosphorylation posttranscriptional RNA processing uridine zinc

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中文摘要

翻译

我们的实验室一直专注于apoB mRNA编辑作为一个模型

英文摘要

Our lab has focused on apoB mRNA editing as a model of post-transcriptional base modification in humans. ApoB mRNA editing is a site specific deamination of a cytidine residue to a uridine at nucleotide position 6666 in the ApoB mRNA transcript. The deamination reaction is a zinc dependent process mediated by a cytidine deaminase referred to as apolipoprotein B editing component 1 (APOBEC-1). RNA editing activity of APOBEC-1 is strictly dependent on assembly of an enzyme complex that includes APOBEC-1 (the catalytic subunit), and auxiliary proteins. During the past year, we have examined regulation of apoB mRNA editing by analysis of post-transcriptional protein phosphorylation.

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