CONSULTATION IN BIOSTATISTICAL METHODOLOGY AND CANCER CONTROL

这个项目的目的是提供独立的 向NCI内部的研究人员咨询问题 与生物统计学方法论和癌症控制有关。 目前的项目包括： -与癌症预防研究合作 美国退休人员协会(AARP)分会 观察性队列研究已经进入第二个年头； 在过去的一年里，邮寄的基线食物频率 超过600,000人填写并返回了调查问卷 美国退休人员协会成员；潜在参与者 选择并登记验证/校准子研究； 通过电话获得了两次24小时饮食召回， 2,000个子研究对象；结果目前正在 进入计算机形式，不久将开始分析； 该项目将建立一个美国退休人员协会成员队列，以 调查他们目前的饮食与饮食之间的关系 摄入量和他们未来乳腺癌的发病率， 结肠/直肠和前列腺。 -与癌症预防研究合作 分部，我们完成了关于膳食叶酸的研究项目 摄入与结直肠癌以及2)饮食的影响 脂肪和纤维摄入量对雄激素和雌激素水平的影响 男人。 -与癌症预防研究合作 和应用研究科，这是一个新发展的 正在评估食物频率调查问卷(FFQ)； 参与者目前正在参加一项研究，使用 每日精选食物清单，用以评估食物 问卷抽样调查项目的频率准确性； 对RFP的回应，用于评估新的 问卷对所选营养素的测量误差 并将它的误差与另外两个常用的 对FFQ进行了评估，选择了一个方案进行奖励，并 谈判目前正在进行中；强劲的回归 将食物频率转换为营养的方法 基于受试者的年龄、性别和FFQ的摄入量-报告 正在开发和评估分量大小。 -与政治部应用研究部协商 和癌症传播办公室，评估 癌症信息系统向公众提供服务的准确性 普通公众仍在继续。 -与流行病学和生物统计学合作 DCEG计划，来自病例对照研究的饮食数据 目前正在对女性肺癌的风险进行检查。 -与化学预防实验室协商， DCEG，我们分析了关于 转化生长的抑瘤活性 因子-(转化生长因子-β)和一项实验结果 雷洛昔芬联合应用抗前列腺癌作用的研究 9-顺式维甲酸或4-HPR。 -与预防和控制中心合作 校外处，该科就以下事项提供咨询 NCI‘s 5 A Day计划的分析与评价 加大果蔬消费力度。 -与环境流行病学合作 分支、DCEG、细胞色素P4501A2的性别差异为 正在接受与饮食差异有关的调查 入口处。

The purpose of this project is to provide independent consultation to researchers within the NCI on problems related to biostatistical methodology and cancer control. Current projects include: - in collaboration with the Cancer Prevention Studies Branch, the American Association of Retired Persons (AARP) Observational Cohort Study has entered its second year; during the past year, the mailed baseline food frequency questionnaire was completed and returned by over 600,000 AARP members; potential participants in a validation/calibration substudy were selected and enrolled; two 24-hour diet recalls were obtained by telephone for the 2,000 substudy subjects; the results are currently being entered into computer form and analysis will soon begin; this project will construct a cohort of AARP members to investigate the relationship between their current dietary intake and their future incidence of cancer of the breast, colon/rectum, and prostate. - in collaboration with the Cancer Prevention Studies Branch, we completed research projects on 1) dietary folate intake and colorectal cancer and 2) the effects of dietary fat and fiber intake on androgen and estrogen levels in men. - in collaboration with the Cancer Prevention Studies Branch and the Applied Research Branch, a newly developed food frequency questionnaire (FFQ) is being evaluated; participants are currently being enrolled in a study using a daily checklist of selected foods to evaluate the food frequency accuracies of a sample of questionnaire items; the responses to an RFP for estimating the new questionnaire's measurement errors of selected nutrients and comparing its error to that of two other commonly used FFQs were evaluated, a proposal was selected for award and negotiations are currently underway; robust regression methods to convert food frequencies into nutritional intakes based on the subject's age, gender and FFQ-reported portion size are being developed and evaluated. - in consultation with the Applied Research Branch, DCPC and the Office of Cancer Communications, evaluatating the accuracy of the Cancer Information System services to the general public is continuing. - in collaboration with the Epidemiology and Biostatistics Program of the DCEG, dietary data from a case control study of lung cancer in women are currently being examined. - in consultation to the Laboratory of Chemoprevention, DCEG, we analyzed results of a study on the tumor-suppressor activity of the transforming growth factor- (TGF-beta) and the results of an experiment of the anti-prostate tumor effect of combining raloxifene with either 9-cis-retinoic acid or 4-HPR. - in collaboration with the Prevention and Control Extramural Branch, the Section provides consultation on the analysis and evaluation of the 5 A Day Program -- NCI's campaign to increase fruit and vegetable consumption. - in collaboration with the Environmental Epidemiology Branch, DCEG, gender differences in cytochrome P4501A2 are being investigated in relation to differences in dietary intake.