ASSEMBLY OF THE ACETYLCHOLINE RECEPTOR

烟碱型乙酰胆碱受体(AChR)是一个五聚体 膜蛋白，其亚基组成为α2β-伽马-三角洲。 五个亚基在其中心形成离子通道，其开口和 关闭是由乙酰胆碱的结合控制的。尼古丁 肌肉中的乙酰胆碱受体是神经递质大家族中研究最多的。 受体包括GABA甘氨酸受体和神经AChR。 谷氨酸受体是根据类似的模式形成的，但 有更远的亲戚关系。我们的实验室研究了它的结构，功能， 以及烟酸乙酰胆碱受体在肌肉中的组装。我们调查了两个 中国人肌肉细胞和异种细胞中受体的特性 其中，AChR在受体亚单位基因转染后表达。 由于家庭成员的相似性，研究结果表明 作为其他受体的模型，这些受体是AChR的靶标 与治疗精神疾病有关的药物。

The nicotinic acetylcholine receptor (AChR) is a pentameric integral membrane protein with the subunit composition of alpha2beta-gamma-delta. The five subunits form an ion channel at their center whose opening and closing is controlled by the binding of acetylcholine. The nicotinic AChR in muscle is the best-studied of a large family of neurotransmitter receptors that include the receptor for GABA glycine and the neural AChR. Glutamate receptors are formed according to a similar pattern, but are more distantly related. Our laboratory studies the structure, function, and assembly of the nicotinic AChR in muscle. We investigate both the properties of the receptors in muscle cells and in heterologous cells in which the AChR is expressed after transfection of receptor subunit cDNA. Because of the similarity of members of the family, findings that related to the AChR serve as a model for other receptors, which are targets for drugs that are relevant to the treatment of mental illness.