IMPLANTABLE BLOOD PRESSURE AND ECG TELEMETRY

在拟议的努力下，一个可植入的遥测发射器将 开发用于长期监测血压、心电和 老鼠和其他大小相当的啮齿动物的体温。的主要关注点 该项目是开发一款应用程序专用的集成 用于发射机电子设备的电路(ASIC)，具有 感知多个生理信号，同时实现大小目标， 重量、可靠性、测量稳定性和使用寿命。通过 结合ASIC，发射器将在体内完全可编程， 具有运行模式和节电功能，使其能够长时间- 多窝动物的术语。该项目还将开发一种 小型压力传感导管、改进的包装方法以及 在体内对发射器进行编程的装置。圆满完成 拟议中的研究将成为生物医学的重要工具 研究人员涉及整个动物生理学。概念设计是 申请人现有的遥测产品基础为 实验动物。作为一种产品，开发的遥测系统将是 整合到申请人现有的分销渠道中， 目前为30个国家和地区的725个客户提供服务。 拟议的商业应用：该设备将提供可靠的、 在制药行业广泛应用的高性价比工具 行业作为一种使用复杂的鼠标模型评估新技术的手段 制药公司。它还将在其他领域有商业应用 生物医学研究，需要测量血压 从实验室动物，包括制药行业，学术 世界各地的机构和政府实验室。

Under the proposed effort, an implantable telemetry transmitter will be developed for the chronic monitoring of blood pressure, ECG, and temperature in mice and other comparably-sized rodents. The main focus of the project is the development of an application specific integrated circuit (ASIC) for the transmitter electronics, with the capability of sensing multiple physiological signals, while achieving goals for size, weight, reliability, measurement stability, and operating lifetime. By incorporating an ASIC, the transmitter will be fully programmable in vivo, with operating modes and power-saving features that will permit its long- term use for multiply-housed animals. The project will also develop a small pressure sensing catheter, an improved packaging method, and a device to program the transmitter in vivo. Successful completion of the proposed research will result in an important tool for biomedical researchers involved in whole animal physiology. The conceptual design is an outgrowth of the applicant's existing base of telemetry products for laboratory animals. As a product, the telemetry system developed will be integrated into the applicant's existing distribution channels, which currently services 725 customers in 30 countries. PROPOSED COMMERCIAL APPLICATION: The device will provide a reliable, cost-effective tool for widespread application in the pharmaceutical industry as a means of using sophisticated mouse models for evaluating new pharmaceuticals. It will also have commercial application in other areas of biomedical research, which blood pressure measurements are required from laboratory animals, including pharmaceutical industries, academic institutions, and government labs world-wide.