IDENT OF H PYLORI VIRUL FACTORS IN ETHNIC POPULATIONS

描述（取自应用程序） 幽门螺杆菌（Hp）是一种常见的全球性感染;目前已知， 在病因上与胃炎、消化性溃疡病、胃 腺癌和原发性胃淋巴瘤。Hp感染的结局 在不同的种族群体中是不同的。例如，在美国， 尽管在所有种族中都检测到Hp感染， 在西班牙裔、黑人、越南人、韩国人、日本人和 美国印第安人，与白色人口相比。可能因素 造成这些差异的原因包括宿主或 环境因素（例如，饮食中）或毒力差异 在一个种族群体中流行的常见Hp菌株。虽然环境 或宿主因素可能是重要的，毒力的差异是一个重要因素。 可能的可能性，因为在许多其他细菌性疾病中， 一种疾病的发生可能与特定的毒力因子直接相关。数据 来自许多实验室的研究表明， 存在.推定的毒力标记，如cagA和vacA基因及其 蛋白质产物，也已确定，它们可能是差异 存在或表达于不同的Hp相关胃肠道疾病中。我们 主要假设是Hp感染的不同疾病表现 不同种族群体之间的差异反映了 优势Hp菌株中不同毒力因子的表达 在族群中流传。本研究的具体目标是： 确定是否存在Hp毒力因子，包括遗传 和/或不同种族内Hp分离株的表型变异 在美国，可能与胃炎的严重程度、范围或模式相关。 我们还计划使用DNA指纹法，REP-PCR，以评估 不同种族间幽门螺杆菌分离株的遗传相似性 组这项研究还将确定患病率的差异是否 特异性候选毒力因子的异质性可能是 导致不同程度和严重程度的潜在机制 中国不同民族人群幽门螺杆菌相关性胃损害和疾病 美国的

DESCRIPTION (taken from the application) Helicobacter pylori (Hp) is a common worldwide infection; it is now known to be etiologically related to gastritis, peptic ulcer disease, gastric adenocarcinoma, and primary gastric lymphoma. The outcome of Hp infection differs among different ethnic groups. For example, in the United States although Hp infection is detected in all ethnic groups, gastric cancer is more common in Hispanics, Blacks, Vietnamese, Koreans, Japanese, and American Indians, compared to the white population. Possible factor(s) responsible for these differences include subtle distinctions in host or environmental factors (e.g., in diet) or differences in virulence in the common Hp strain(s) circulating within an ethnic group. While environmental or host factors are likely to be important, differences in virulence is a likely possibility because in many other bacterial diseases the expression of a disease can be directly related to specific virulence factors. Data from a number of laboratories suggest that different groups of Hp strains exist. Putative virulence markers, such as cagA and vacA genes and their protein products, have also been identified and they may be differentially present or expressed in different Hp-related gastrointestinal diseases. Our primary hypothesis is that different disease manifestations of Hp infection in different ethnic groups is a reflection of the heterogeneity and expression of different virulence factors in the predominant Hp strain(s) circulating in the ethnic group. The specific objectives of this study are: To determine whether the presence of Hp virulence factors, including genetic and/or phenotypic variations in Hp isolates within different ethnic groups in the US, can be correlated with severity, extent, or pattern of gastritis. We also plan to use the DNA fingerprinting method, REP-PCR, to assess genetic similarity among Hp isolates within and between different ethnic groups. This study will also determine whether differences in prevalence and heterogeneity of specific candidate virulence factors may be the underlying mechanism leading to differences in the extent and severity of Hp-related gastric damage and diseases in different ethnic groups in the United States.