ADULT AIDS CLINICAL TRIALS UNIT

西班牙裔，黑人和妇女受到不成比例的影响， 艾滋病流行。 尽管这些少数民族的艾滋病病例负担增加， 在人口中，获得临床试验的机会仍然很低。 波多黎各 在所有州和地区中，艾滋病病例数居第二位， 100 000（51.4）。 艾滋病是20-40岁年龄组的主要死因 范围组。 在过去5年中， 异性性传播和妇女感染已得到证实。 在过去的三年里，我们已经确定并开发了所有 建立ACTU所需的基础设施组成部分， UPR校医。 这项努力已经发展成为一项研究， 单位拥有优良的设施、骨干科研人员、配套服务 和社区参与。 在过去的6个月里，我们被允许入组ACTG 175的患者。 在3个月的时间里，我们评估了65名候选人，并从所有候选人中获得了16名。 风险行为群体。 截至12月，1992年，共进行了112次后续访问 只有一次失约（访视完成率 99%）。 仅1例患者因依从性差而停药， 两名患者能够维持其参与方案 成功地将他们转移到美国的ACTU。 那么，当务之急是，一个成年ACTU在公关。使用作为 研究工具和作为一个急需的治疗替代品。

Hispanic, blacks and women have been disproportionately affected by the AIDS epidemic. Despite increased burden of AIDS cases in these minority populations, access to clinical trials remain low. Puerto Rico (P.R.) ranks second, within all states and territories, in AIDS cases per 100,000 (51.4). AIDS is the leading cause of death for the 20-40 age range group. During the past 5 years, highly significant increments in heterosexual transmission and infection in women have been demonstrated. During the past 3 years we have identified and developed all the necessary infrastructure components for the establishment of an ACTU at the U.P.R., School Medicine. This effort has matured into a research unit with excellent facilities, key research staff, ancillary services and community participation. During our last 6 months we were allowed to enroll patients in ACTG 175. In a 3 month period we evaluated 65 candidates and accrued 16 from all risks behavior groups. As of Dec., 1992, a total of 112 follow-up visits had been recorded with only one missed appointment (visit completion rate of 99%). Only 1 patient was discontinued because of poor compliance and two patients were able to maintain their participation in the protocol by successfully transferring them to ACTU's in USA. It is then, imperative, that an adult ACTU in P.R. be available as a research tool and as a much needed therapeutic alternative.