MAP THE SUSCEPTIBILITY GENE IN CHINESE SLE SIBPAIRS

本FIRCA申请的父项目是R 01赠款， 确定五个候选人类染色体区域是否赋予主要的 SLE的易感性。 用小鼠法鉴定候选区域 同源物，并将通过连锁和关联方法进行研究， 通过UCLA诊所确定了300个多重家庭， 是一个种族混杂的混合体，因为 假设是SLE易感基因将在整个基因组中保守， 种族群体。 该小组报告了SLE与 染色体1 q41-q42上的标记和非参数等位基因共享方法 在受影响的同胞对之间似乎表明， 的等位基因共享发生在亚洲亚组，其中包括10个同胞， 两对南方汉族后裔。 希望在一个种族同质的子集中扩展这一发现， 博士曹提议与该部门的调查人员合作 中国上海仁济医院的流变学博士。 的目标 FIRCA基金将用于识别和招募100名中国SLE患者同胞 家庭，基因型血液样本或口腔拭子与标记密集 位于候选区域，并使用 非参数关联方法。

The parent project for this FIRCA application is an R01 grant to determine whether five candidate human chromosomal regions confer major susceptibility to SLE. The candidate regions were identified by mouse homologues, and will be studied by linkage and association methods in 300 multiplex families ascertained through UCLA clinics, which was intended to be an ethnically heterogeneous mix, since one of the hypotheses is that SLE-predisposing genes will be conserved across ethnic groups. This group has reported evidence for linkage of SLE to markers on chromosome 1q41-q42, and nonparametric allele sharing methods among affected sib pairs seemed to suggest that the greatest proportion of allele sharing occurred in the Asian subset, which included 10 sib pairs of southern Han Chinese descent. Wishing to extend upon this finding in an ethnically homogeneous subset, Dr. Tsao proposes a collaboration with investigators in the Department of Rheumatology at Ren Ji Hospital in Shanghai, China. The goals of the FIRCA grant are to identify and enroll 100 Chinese SLE-affected sibpair families, to genotype blood samples or buccal swabs with markers densely located in the candidate region, and to analyze the data using nonparametric linkage and association methods.