1998 GORDON CONFERENCE ON TETRAPYRROLES

描述：支持第17届戈登研究会议 四吡咯的化学和生物学要求。 这个两年期 跨学科会议促进了基本 生物学家，化学家和临床医生对四吡咯的兴趣超过 三十年了 与蛋白质结合，四吡咯提供多种功能， 作为生物氧化还原催化剂，用于收集光能， 氧活化/输送以及作为信号分子。 游离四吡咯 也是必需的营养素（如维生素B12），作为基因的调节剂， 表达（例如血红素），并且已经被用作治疗剂（例如， 光动力癌症治疗、靶向递送或放射性核素）。 由于 它们的光动力活性、毒性和亲脂性、 四吡咯（例如卟啉胆红素）与许多 皮肤、肝脏和大脑的病理。 由于这些原因，这 会议是一个重要的场所之间的交流基础和 四吡咯的应用研究人员和改进新工具， 生物医学行业正在开发的疗法。 资金 本申请中要求的目标是支持10名年轻的研究人员 他们以前没有机会参加这次会议。 两 新的会议已被添加，将展示新的进步，从年轻的 调查人员，并强调了最近的进展，从行业。 将有21 特邀演讲人，一名全体演讲人和8名讨论领导人， 因其卓越的科学成就，最近的创新工作和广度而被选中 的计划。 其余100名与会者将被选中，以确保 妇女、族裔和青年科学家的广泛代表性， 学术、医学研究机构和工业界的学科。 这个正在进行的戈登会议的优势是其学科的多样性; 专注于新的未发表的工作，讨论时间，非正式的气氛， 禁止散发会议记录。

DESCRIPTION: Support for the 17th Gordon Research Conference on the Chemistry and Biology of Tetrapyrroles is requested. This biennial interdisciplinary conference has stimulated collaborations between basic biologists, chemists an clinicians interested in tetrapyrroles for more than three decades. In association with proteins, tetrapyrroles serve diverse roles as biological redox catalysts, for harvesting of light energy, for oxygen activation/deliver and as signaling molecules. Free tetrapyrroles are also essential nutrients (e.g. vitamin B12), serve as regulators of gene expression (e.g. hemes), and have been utilized as therapeutic agents (e.g. photodynamic cancer therapy, target delivery or radionuclides). Owing to their photodynamic activity, toxicity and lipophilicity, the accumulation of tetrapyrroles (e.g. porphyrins bilirubin) is associated with numerous pathologies of the skin, liver and brain. For these reasons, this conference represents an important venue for exchange between basic and applied researchers on tetrapyrroles and for refinement of new tools and therapies that are under development by the biomedical industry. Funds requested in this application are targeted to support 10 young investigators who have not previously had the opportunity to attend this conference. Two new sessions have been added that will showcase ne advances from young investigators and highlight recent progress from industry. There will be 21 invited speakers, a plenary lecturer and 8 discussion leaders who have been selected for their scientific excellence, recent innovative work and breadth of the program. The remaining 100 conferees will be chosen to ensure a broad representation of women, ethnicity and young scientists from various disciplines in academic, medical research institutions and industry. Strengths of this ongoing Gordon Conference are its disciplinary diversity; focus on new unpublished work, time for discussion, informal atmosphere, and ban on dissemination of conference proceedings.