Discovering New Chemistry and Potential Applications of Metal Tetrapyrroles

发现金属四吡咯的新化学和潜在应用

• 批准号: DP200100178
• 负责人: Prof Paul Donnelly
• 金额: $ 31.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100178
• 关键词: Discovering; New; Chemistry; Potential; Applications

This project aims to make fundamental advances in inorganic chemistry, coordination chemistry and bioinorganic chemistry by preparing new metal-containing molecules based on specifically designed tetrapyrrole ligands. Innovative synthetic methods will be developed to enable systematic chemical modifications to explore the chemical and biological properties of the metal complexes. The potential of the new molecules to be of use as tracers for molecular imaging will be investigated. An expected outcome of this research will be an increased understanding of how chemical properties dictate the biological activity of metal complexes informing the potential long-term translation of this chemistry to to new molecular diagnostics and therapeutics.

该项目旨在通过制备基于特殊设计的四吡咯配体的新型含金属分子，在无机化学、配位化学和生物无机化学方面取得根本性进展。将开发创新的合成方法，使系统的化学修饰能够探索金属络合物的化学和生物特性。新分子作为示踪剂用于分子成像的潜力将被研究。这项研究的预期结果将是更多地了解化学性质如何决定金属配合物的生物活性，从而使这种化学的潜在长期转化为新的分子诊断和治疗学。