APPRAISAL OF INTERVENTIONS--PROSTATE CARCINOMA

描述（申请人的描述）：前列腺癌是最常见的癌症。 诊断为男性实体瘤。 尽管在早期检测方面有所改进，但许多 患者基于升高的血清前列腺特异性抗原而进展。 常规治疗可能会减缓进展，但很少治愈晚期或晚期。 进行性疾病 为了改善结果，许多男性寻求替代或 他们从新闻界了解到的非传统方法， 互联网和其他非医疗来源。 由于干预措施是在 主流医学，很少有医生知道这些选择，也没有准备好 为病人提供咨询 由于人们对替代能源的兴趣日益浓厚， 医学，一个为病人和医生召开的会议， 非常规战略是必要的，也是及时的。 这个的目标 会议的目的是（1）批判性地评估现有的支持数据， 非传统替代战略的潜在影响， 一般是恶性肿瘤或特别是前列腺癌，（2）改善 提高医生对现有替代干预措施的认识， 医生可以为病人提供咨询，个人可以决定 是否纳入干预措施，以及（3）确定潜在的试点 研究和其他研究机会， 非常规干预的潜在价值。 这将是 通过15分钟的演讲完成14个主题， 干预措施，可分为饮食，食品补充剂和提取物， 维生素、矿物质、草药和动物提取物。 每次演讲后， 主持人将向发言者提出问题，以批判性地评价 主题是为了给观众提供三个问题的答案： (1)现有信息是否支持现在纳入干预措施 而等待更明确的科学研究，如果没有，（2）是 信息足以引起争议，应启动试点研究 如果患者积极参加，或（3）信息如此有限， 模糊，或缺乏任何客观数据，需要进一步的基础研究 在考虑使用它们之前？ 书面提问 听众将以书面形式征求，并转达给发言者， 这将有助于回答上述问题。 每一位演讲者都将 向主持人提供他们的谈话，包括轶事案例， 最佳问题可以在会议之前准备好。

DESCRIPTION (Applicant's Description): Prostate cancer is the most commonly diagnosed solid tumor in men. Despite improvements in early detection, many patients progress based on a rising serum prostate specific antigen. Conventional therapies may slow progression but rarely cure advanced or progressive disease. To improve outcome, many men look to alternative or unconventional approaches which they learn about from the lay press, the internet and other non medical sources. Since the interventions are outside mainstream medicine, few physicians are aware of these options nor prepared to offer patient counseling. Because of growing interest in alternative medicine, a conference for patients and physicians which critically reviews unconven-tional strategies is both necessary and timely. The goals of this conference are (1) to critically evaluate the existing data supporting the potential impact of unconventional alternative strategies as they relate generally to malignancy or specifically to prostate cancer, (2) to improve awareness among physicians about existing alternative interventions so that physicians are able to counsel their patients and individuals can decide whether to incorporate an intervention, and (3) to identify potential pilot studies and other research opportunities which would further knowledge about the potential value of unconventional interventions. This will be accomplished by a 15 minute presentation on each of 14 topics involving interventions which can be divided into diet, food supplements and extracts, vitamins, minerals, herbs and animal extracts. Following each talk, a moderator will direct questions to the speaker to critically appraise the topic in order to leave the audience with the answers to three questions: (1) does the existing information support incorporating an intervention now while awaiting more definitive scientific studies, and if not, (2) is the information sufficiently provocative that pilot studies should be initiated and should patients actively enroll, or (3) is the information so limited, vague, or lacking any objective data that further basic studies are needed before consideration is given to their use? Written questions from the audience will be solicited in writing and relayed to the speaker providing that they will help answer the above questions. Each of the presenters will provide the moderator with their talk including anecdotal cases so that optimal questions can be prepared before the conference.