PROBIOTICS IN NEONATAL GUT MICROBIAL ECOLOGY

这项研究的长期目标是确定病因学和 早产儿肠道功能障碍的发病机制。 首席调查员观察到分离出的革兰氏阴性菌株 在断奶的兔回肠回肠模型中，来自婴儿的病毒会导致细胞损伤。 已从以下患者中分离出多种革兰氏阴性菌/种 私家侦探的机构。这些菌株中的大多数都能够产生 组织损伤动物模型。虽然疾病的确切机制 目前尚不清楚，肠道中是否存在细菌已被提出 这是胃肠道疾病发展过程中最重要的因素之一。这个 目前的建议将检查早产儿的细菌菌群 并将尝试检查疾病和细菌之间的任何联系，此外 在这种医疗和社会文化环境中的饮食习惯。

The long term goal of this research is to define the etiology and pathogenic mechanisms of intestinal dysfunctions in the premature infants. The principal investigator has observed that Gram negative strains isolated from infants can cause cell injury in a weanling rabbit ileal loop model. Multiple Gram negative strains/species have been isolated from patients in the PI's institution. Most of these strains are capable of producing tissue injury in the animal model. While the precise mechanisms of disease are not clear, presence of bacteria in the bowel has been proposed to be one of the most important factors in the development of GI disease. The current proposal will examine the bacterial flora of premature infants in India and will try to examine any link between disease and bacteria, plus feeding habits in that medical and socio-cultural setup.