FUNCTIONAL STREAMS IN THE PRIMATE VISUAL CORTEX

描述：首席调查员和他的团队建议扩大我们的 对巨细胞和小细胞功能的认识 灵长类视觉中的溪流，特别是它们与 细胞色素氧化酶斑块的解剖学识别神经群 以及V1和V2区域的条纹。这将通过记录神经网络来实现 用光学方法和方法从猕猴的视皮层中获得活动 用扩展的卡尔胡宁-洛夫(KL)原理分析图像 组件方法。此方法将提供有关 协调活动的空间和时间分布。他们建议 这些信息包含在少数空间隔离的 动态分量，其中一些分量对应于已知的 皮质结构，如眼优势柱。这项研究将1) 研究已知神经元亚群(STREAM)对 光学监测神经元活动的两种互补方法 方法：a)使用主要刺激一个细胞的视觉刺激 诸如M-STREAM和b)沉默选定神经元的群体 通过将镁离子或利多卡因压力注射到大脑的部分脑区 外侧膝状核，2)比较CO记录的光信号 与从斑点间区域记录的斑点，3)比较光学 活度图与CO斑点的分布，以及4)将 具有同时记录的电活性的光学活性 皮质神经元。公安局相信，这些组合的装置将 揭示视觉皮质和意志的进一步组织原则 加深我们对其组成部分的功能的理解。

DESCRIPTION: The Principal Investigator and his team propose to expand our understanding of the functions of the magnocellular and parvocellular streams in primate vision and especially their relationships to the anatomically identified neural populations of the cytochrome oxidase blobs and stripes in areas V1 and V2. This will be achieved by recording neural activity from the visual cortex of macaque monkeys using optical methods and analyzing the images with extensions of the Karhunen-Loeve (KL) principle component methods. This approach will provide information about both the spatial and temporal distributions of coordinated activity. They suggest that this information is contained in a small number of spatially segregated dynamical components and that some of these components correspond to known cortical structures such as ocular dominance columns. The study will 1) investigate the contributions of known neuronal subpopulations (streams) to the optically monitored neuronal activity by using two complimentary methods: a) use of visual stimuli that excite primarily one cell populations such as the M-stream and b) silence selected neuronal populations by pressure injections of Mg++ or lidocaine into portions of the lateral geniculate nucleus, 2) compare optical signals recorded from CO blobs with those recorded from interblob regions, 3) compare the optical activity maps with the distribution of CO blobs, and 4) correlate the optical activity with simultaneously recorded electrical activity of cortical neurons. The PI believes that these combined apparoches will reveal further organizational principles of the visual cortex and will deepen our understanding of the functions of its constituent streams.