RESORBABLE STRUCTURES

由于创伤或手术而切除的组织的原位再生可以 由一个支撑脚手架方便，该脚手架被塑造成缺失的部分，以及 含有在支架内生长的自体细胞。因为他们的 生物降解性和生物兼容性，以及它们对 控制孔径和孔径分布，PLGA泡沫塑料具有潜力 作为神经再生指南的应用。初步研究，在 与莱希诊所的合作表明，我们的PLGA泡沫 成功地支持神经再生超过10毫米的缝隙。这个 再生的神经纤维能够通过三维 泡沫的脚手架，此外，再生的电缆显示 与对照指南相比，显著增强了新生血管。这个 第一阶段的具体目标将确定增强的可行性 可吸收泡沫PLGA结构周围神经再生的实验研究 控制形态现在掺入外源胶质生长因子或 雪旺细胞。如果这导致当前的再生能力增强 周围神经移植的标准，最终的临床目标将是 将这种掺杂的可吸收结构应用于&gt；10 mm的间隙。 建议的商业应用： 生物医学材料代表着一个不断增长的市场。预计用途为 药物输送，以及其他，植入，修复和移植 申请。我们的专利泡沫塑料的示范应用 可重复性均匀的形态可能会在 专门的医疗保健部门。

The in situ regeneration of tissues, excised due to trauma or surgery, can be facilitated by a supporting scaffold, shaped to the missing parts, and containing autologous cells grown within the scaffold. Because of their biodegradability and biocompatibility, as well as their amenability to controlled pore size and pore size distribution, PLGA foams have potential application as guides for nerve regeneration. Preliminary studies, done in collaboration with the Lahey Clinic, have shown that our PLGA foams successfully support nerve regeneration over gaps of 10 mm. The regenerating nerve fibers are able to negotiate the 3-dimensional scaffolding of the foam, and, in addition, the regenerated cables show significantly enhanced neo-vascularity, as compared to control guides. The specific aims of Phase I will establish the feasibility of enhanced peripheral nerve regeneration using this resorbable foam PLGA structure of controlled morphology now doped with exogenous Glial growth factors or Schwann cells. If this results in enhanced regeneration over the current standard of peripheral nerve grafting, the ultimate clinical goal would be to apply this doped resorbable structure to gaps of > 10 mm. PROPOSED COMMERCIAL APPLICATION: Biomedical materials represent a growing market. Uses are projected for drug delivery, as well as other, implant, repair, and transplant applications. Demonstrated applications of our patented foams of reproducibility homogeneous morphologies would potentially find utility in specialized health care segments.