COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA

描述：该应用程序为社区卫生服务提供了一个独特的机会 评估痴呆症风险的主要决定因素和具体类型 人群样本中的痴呆症。它建议检验这样一个假设： MRI改变，包括梗死样病变(ILS)，高白质分级， 高脑沟分级、高脑室分级和局灶性脑萎缩 与3660名心血管疾病患者中痴呆症风险增加有关 在1992-93年间接受首次核磁共振检查的健康研究参与者， 许多人在1997-98年间进行了第二次核磁共振检查，现在大约82岁了。 我们的计划是评估载脂蛋白E(ApoE)与 基因型、炎症指标、亚临床心血管疾病，以及 突发临床疾病(包括中风和心肌梗塞)， 心血管危险因素，如高血压和糖尿病，以及 痴呆症与这些MRI变量的关系。这些产品的大部分数据 自变量已经收集好了。将会有524辆黑色 样本中的参与者。所有参与者都将有详细的 神经心理测试与临床、神经学和精神病学 来自近亲和举报人的评估信息，以确定 根据所有可能的痴呆症诊断分类 来自CHS、神经心理学和临床的可用信息 神经精神病学评估。申请书显示，社区卫生服务中心 将能够确定MRI表现，特别是与两者相关的 血管疾病、脑室分级和海马体体积是主要的 痴呆症的预测因素和痴呆症的类型，特别是与 载脂蛋白E、炎症标志物、认知功能前期评分的测量 测试，可能还有亚临床血管疾病。我声明，这些 关系将足够牢固，以便及早采取更好的方法 确定易患痴呆症的对象，并可能采取新的方法 为了预防。

DESCRIPTION: The application presents the CHS as a unique opportunity to evaluate major determinants of the risk of dementia and specific type of dementia in a population sample. It proposes to test the hypothesis that MRI changes, including infarct-like lesions (ILLs), high white matter grade, high sulci grade, high ventricular grade, and focal brain atrophy are associated with an increased risk of dementia among the 3660 Cardiovascular Health Study participants that had their initial MRI in 1992-93 and, for many, a second MRI in 1997-98 and are now approximately 82 years of age. The plan is to evaluate the relationship between apolipoprotein E (ApoE) genotype, measures of inflammation, subclinical cardiovascular disease, and incident clinical diseas (including stroke and myocardial infarction), cardiovascular risk factors such as hypertension and diabetes, and risk of dementia in relation to these MRI variables. Most of the data for these independent variables have already been collected. There will be 524 Black participants in the sample. All of the participants will have detailed neuropsychological testing and clinical, neurological, and psychiatric evaluation information from next-of-kin and informants in order to determine classification of a possible diagnosis of dementia based on all the available information from the CHS and the neuropsychological and clinical neurological psychiatric evaluation. The application suggests that the CHS will be able to determine whether MRI findings, specifically related to both vascular disease, ventricular grade and hippocampal volume are major predictors of dementia and type of dementia, especially in combination with measurements of ApoE, markers of inflammation, prior scores on cognitive tests and, possibly, subclinical vascular disease. I states that these relationships will be strong enough to allow better methods for early identification of subjects at-risk of dementia and, possibly, new approaches to prevention.