ACTIVITY INTERVENTION IN WOMEN A DECADE LATER

描述：（改编自研究者摘要）十年前， 临床试验结束了，该试验一直在检查步行的影响， 匹兹堡市229例绝经后妇女骨密度干预研究 在为期2.5年的研究结束时，干预妇女被发现， 根据活动调查， 活动监控。 这项临床试验的一个里程碑是， 80%的干预妇女达到创纪录的依从性 报告了平均每周步行5英里的最低估计， 2.5多年的临床试验。 参加这次会议的妇女 1995年重新联系了最初的临床试验， 电话，以了解他们目前的活动水平和健康状况; 90%的 最初的参与者被成功追踪。 基于 报告的活动数据，干预妇女似乎有 与对照组相比， 妇女 此外，还有一个显着的差异之间指出， 两个随机分组的10年心脏病发病率 疾病 干预组中有两名妇女报告患有心脏病 与11名对照组妇女相比（相对危险度= 0.18）。 这样做的目的 目前的应用程序是再次联系这些妇女， 报告的冠心病发病率差异很大 两个随机分组之间的差异，并确定两个 干预组在身体活动的客观测量方面有所不同， 冠心病危险因素和骨密度。心脏病会 通过对医院报告、医生 接触和广泛的病史。 身体活动监测器 将在本研究中使用，以获得当前的客观措施 活动 骨密度（AP腰椎、股骨近端和全身） 和全身软组织成分将由双能量 X射线吸收测定法。 将进行超声扫描， 确定颈动脉粥样硬化的程度。 心血管风险因素，如血脂、全身脂肪、空腹 胰岛素和葡萄糖浓度以及静息血压也会 测量并比较两组之间的差异。 调查人员 声明该研究旨在解决公众的一个重要领域， 这将是第一个临床试验，以调查长期 中等强度运动对老年妇女的长期影响。

DESCRIPTION: (Adapted from Investigator's Abstract) Ten years ago, a clinical trial ended, which had been examining the effects of a walking intervention on bone density in 229 post-menopausal women in Pittsburgh. At the end of the 2.5 year study, the intervention women were found to be more active than the control women based upon activity surveys and activity monitors. A milestone of this clinical trial was that it achieved record-setting compliance with 80% of the intervention women reporting a minimum weekly walking estimate of 5 miles averaged over the 2.5 years of the clinical trial. The women who participated in the original clinical trial were re-contacted in 1995 and interviewed by phone to obtain their current activity levels and health status; 90% of the original participants were successfully traced. Based upon the reported activity data, the intervention women appeared to have maintained higher physical activity levels compared to the control women. In addition, there was a striking difference noted between the two randomized groups in the 10-year incidence of reported heart disease. Two women in the intervention group reported heart disease compared to 11 control women (relative risk=0.18). The purpose of this current application is to contact these women again to validate the large differences in incidence of coronary heart disease reported between the two randomized groups and to determine if the two intervention groups differ by objective measures of physical activity, coronary heart disease risk factors and bone density. Heart disease will be validated through an evaluation of hospital reports, physician contacts and extensive medical histories. Physical activity monitors will be utilized in this study to obtain an objective measure of current activity. Bone density (AP lumbar spine, proximal femur and whole-body) and whole-body soft-tissue composition will be determined by dual energy x-ray absorptiometry. Ultrasound scanning will be performed to determine the level of atherosclerosis in the carotid arteries. Cardiovascular risk factors such as lipids, total body fat, fasting insulin and glucose concentrations, and resting blood pressure will also be measured and compared between the two groups. The investigators state that the study is designed to address an important area of public health and would be the first clinical trial to investigate the long term effects of moderate intensity exercise in older women.