BEDSIDE AUDIO VESTIBULAR TESTING SYSTEM

描述：在拟议项目的第一阶段，一个综合的 床边听力前庭筛查测试系统 将开展监测工作。抗肿瘤强效抗生素 药物是救命稻草，但也可能有显著的副作用，包括 耳毒性。一种潜在有效的限制或防止 药物所致的耳蜗性和前庭功能损害 耳毒性是在化疗期间监测患者的状态。 然而，实用的、具有成本效益的耳毒性监测程序， 还有待开发，目前的方法是片面的，专注于 关于他们对内耳的评估中的听力状况。科学 匹兹堡大学研究人员在耳毒性方面的突破 监听与智能听力系统相结合 基于微处理器的仪器和数字信号处理 创新现在提供了必要的技术来实现成本- 有效的床边耳毒性监测。原型系统将是 开发的将结合常规和高频失真 产品耳声发射评估和听力测量以及头部- 只有前庭功能的旋转测试。其有效性和有效性 该设备的可靠性将根据实验室/临床进行评估 在多个人群中进行标准测试。可检测性的极限 耳蜗和前庭功能的显著变化将是 下定决心。这些努力将由一个跨学科小组进行。 利用最先进的技术将可行的产品带到 市场。 建议的商业应用：不可用

DESCRIPTION: In Phase I of the proposed project, an integrated audiovestibular screening and testing system for bedside ototoxicity monitoring will be developed. Antineoplastic and powerful antibiotic drugs are life-savers but can have significant side effects, including ototoxicity. A potentially effective way of limiting or preventing functional impairment from drug-induced cochleo- and vestibulo- ototoxicity is to monitor the patient's status during chemotherapy. Practical, cost-effective programs of ototoxicity monitoring, however, have yet to be developed and current approaches are one-sided, focusing on hearing status in their evaluation of the inner ear. Scientific breakthroughs by University of Pittsburgh researchers on ototoxicity monitoring, in conjunction with Intelligent Hearing Systems' microprocessor-based instrumentation and digital signal processing innovations now provide the necessary technology to perform cost- effective, bedside ototoxicity monitoring. The prototype system to be developed will incorporate conventional and high-frequency distortion product otacoustic emissions assessment and audiometry along with head- only rotational testing of vestibular function. The validity and reliability of the device will be assessed against laboratory/clinical standard tests in multiple populations. The limits of detectability of significant changes in cochlear and vestibular function will be determined. These efforts will be pursued by an interdisciplinary team utilizing state-of-the-art technology to bring a viable product to market. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE