CONTROL AND EXPRESSION OF TYPE 1 PILI IN E COLI

1型皮利;大肠杆菌介导的粘附到各种真核细胞 研究人员合作进行的研究表明， 在“毒力”中的主要作用是促进E.杆菌 动物之间的对话PI的研究集中在1型皮利 与真核细胞的相互作用以及某些微小的菌毛成分 影响菌毛生物发生。其目的是使干预能够在 病原菌的定植和传播，并了解更多关于 聚合超分子结构的组装机理 将军具体目标是1。研究分子间的相互作用， 受体结合和2.研究菌毛组装中的分子相互作用。

Type 1 pili of E. coli mediate adhesion to a variety of eukaryotic cells and the investigator has collaborated in studies that show that their major role in "virulence" is to promote communicability of E. coli from animal to animal. The PI's research focuses on the way that type 1 pili interact with eucaryotic cells and how certain minor pilus components influence pilus biogenesis. The intent is to enable intervention in colonization and spread of pathogenic bacteria and to learn more about mechanisms of assembly of polymerized supramolecular structures in general. Specific aims are 1. Examine the molecular interactions in receptor binding and 2. examine molecular interactions in pilus assembly.