EFFICIENT DESIGN STRATEGIES IN ARTHRITIS RESEARCH

研究的目标是在现实条件下开发有效的设计， 设计临床试验和生物医学应用的假设 问题研究 主要包括三个部分：（1）多目标优化设计 临床试验和生物医学研究中的设计，（ii）开发最佳的 纵向研究的设计，以及（iii）开发有效的设计 了解患者对不同维度的排序偏好， 生活质量评估。 部分（i）和（ii）的结果将提供更有效的设计， 评估治疗方案的变化 此外，设计 这里开发的是更多才多艺，因为他们捕捉的目标， 研究人员更准确。 第（iii）部分的研究结果将 提供了一种有效的方式来了解患者对各种 通过减少调查问卷的负担， 患者 在所有情况下，分析和数值设计将 使用现代技术和图形工具开发。 此外，本发明还提供了一种方法， 用于生成这些设计的计算机算法将被提供给 一般用途。 这里开发的设计都是有效的，可以完成许多 在临床试验中以最少的资源使用实现实际目标。 这在运营成本越来越高的时候很重要 实验和临床试验。

The research goal is to develop efficient designs under realistic assumptions with applications to designing clinical trials and biomedical studies. There are three parts: (1) to develop multiple-objective optimal designs in clinical trials and biomedical studies, (ii) to develop optimal designs for longitudinal studies, and (iii) to develop efficient designs for understanding patients' ranking preferences to different dimensions in quality of life assessment. Results from part (i) and (ii) will provide more efficient designs in evaluating treatment protocols over time. In addition, the designs developed here are more versatile since they capture the goals of the researcher more accurately. Results from part (iii) of the research will provide an efficient way of understanding patients responses' to various health outcome measures by reducing the questionnaire burden on the patients. In all cases, analytical and numerical designs will be developed using modern technique and graphical tools. In addition, computer algorithms for generating these designs will be supplied for general use. The designs developed here are all efficient and can accomplish many practical objectives in clinical trials with a minimum use of resources. This is important in such times when it is increasingly costly to run experiments and clinical trials.