HEMATOPOIETIC PP14--AN ANTIINFLAMMATORY CYTOKINE

描述：PP 14是一种抗炎细胞因子，由以下细胞分泌： 生殖道 Tykocinski博士克隆了一种独特的分子 一种在巨核细胞和血小板中产生的PP 14， PP 14的原核和真核表达系统。 他提议 (1)人造血细胞PP 14及其疏水性的分子研究 配体和受体;（2）进一步表征人 造血细胞PP 14及其体外免疫抑制作用 （3）血小板中的造血PP 14及其潜力的研究 免疫病理学后果;（4）评估体内功能， PP 14在动物模型系统中，预先克隆相应动物后 PP 14同系物。 将检验两个中心假设：（1）PP 14和， 特别地，人造血PP 14具有免疫抑制潜力 作为抗炎细胞因子用于治疗炎性 （2）来自血小板的PP 14在某些疾病中是免疫病理性的。 临床环境。

DESCRIPTION: PP14 is an anti-inflammatory cytokine secreted by cells of the reproductive tract. Dr. Tykocinski has cloned a unique molecular form of PP14 produced in megakaryocytes and platelets and has developed both prokaryotic and eukaryotic expression systems for PP14. He proposes (1) molecular studies of human hematopoietic PP14 and its hydrophobic ligands and receptors; (2) further characterization of human hematopoietic PP14 and its immunosuppressive functions in in vitro systems; (3) studies of hematopoietic PP14 in platelets and its potential immunopathological consequences; (4) assessment of in vivo functions of PP14 in animal model systems, after prior cloning of respective animal PP14 homologues. Two central hypotheses will be tested: (1) PP14 and, in particular, human hematopoietic PP14 has immunotherapeutic potential as an anti-inflammatory cytokine for the treatment of inflammatory disorders; (2) PP14 from platelets is immunopathogenic in certain clinical settings.